Table 5.

Characteristics of hospital admissions according to simple red blood cell transfusion and exchange blood transfusion status.

	Without simple red blood cell or exchange blood transfusion N = 26,334	With blood simple red blood cell transfusion N = 12,746	With exchange blood transfusion N = 244	P value for simple transfusion vs. nontransfused1	P value for exchange transfusion vs. nontransfused1
Baseline
Age, median (IQR)	27 (22–34)	29 (23–36)	26 (22–31)	<0.001	0.004
Female gender (%)	59.4%	63.3%	51.2%	0.007	0.027
Opioid treatment (%)2	74.4%	68.2%	68.4%	0.001	0.5
NSAID treatment (%)2	30.0%	24.1%	29.9%	0.08	0.9
Hydroxyurea treatment (%)2	29.8%	26.5%	25.8%	0.2	0.4
Steroid treatment (%)2	6.0%	5.4%	11.5%	0.5	0.006
Chronic conditions
Cardiopulmonary disease (%)	25.9%	24.7%	32.0%	<0.001	0.030
Chronic Asthma	15.7%	10.7%	14.8%	0.037	0.3
Chronic renal disease (%)	3.3%	6.7%	4.9%	<0.001	0.3
Chronic liver disease (%)	2.8%	3.2%	4.1%	0.3	0.1
Acute comorbidities
Acute chest syndrome or pneumonia	14.6%	21.7%	58.2%	<0.001	<0.001
Acute renal failure	2.7%	5.4%	12.7%	<0.001	<0.001
Sepsis	4.4%	6.7%	11.5%	<0.001	<0.001
Acute multi-organ failure	1.0%	1.9%	12.7%	<0.001	<0.001
Stroke	0.8%	0.9%	9.0%	0.6	<0.001
Acute liver failure	0.2%	0.4%	2.5%	<0.001	<0.001
Hospital course
LOS, mean (95%CI) day	5.4 (5.3–5.5)	6.7 (6.6–6.8)	9.2 (8.1–10.3)	<0.001	<0.001
Mortality	0.5%	0.5%	2.5%	0.8	<0.001

¹Unadjusted

²From outpatient records