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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cytokine. 2015 Jul 11;76(2):549–552. doi: 10.1016/j.cyto.2015.06.019

Fig. 2.

Fig. 2

(A) RSV suppresses VEGFR2 expression and phosphorylation in HUVECs. Cells were pretreated with or without RSV for 16 hours before co-treatment with or without VEGF (25 mg/ml) for another 10 minutes. Western blots with densitometry analysis were performed. Data show that VEGF induced phosphorylation of VEGFR2 (*p<0.05) without influencing total VEGFR2 expression. RSV significantly decreased total VEGFR2 (*p<0.05) and VEGFR2 phosphorylation induced by VEGF (*p<0.05). (B) RSV suppresses VEGFR2 phosphorylation in HUVECs via SIRT1. Methods as in Fig.2B. Knocking down SIRT1 resulted in increased phospho-VEGFR2 expression compared with control siRNA group (*p<0.05).