Table 2.
Top fifteen up- and downregulated genes (p<0.05) by 24 hour treatment with 0.5 μM CdCl2 in HepG2 cells. Fold changes for the other treatments also listed. # fold change >1.25
| Gene Symbol | Gene Description | Fold Change (0.5 μM) |
Fold Change (0.1 μM) |
Fold Change (1.0 μM) |
Regulation |
|---|---|---|---|---|---|
| MT1G | metallothionein 1G | 2.215775 | 1.5027326 | 2.6238236 | up |
| MT1F | metallothionein 1F | 1.9121428 | 1.405878 | 2.2424114 | up |
| MT1M | metallothionein 1M | 1.8444134 | # | 6.988504 | up |
| MT1B | metallothionein 1B | 1.7858652 | # | 5.00817 | up |
| MT1X | metallothionein 1X | 1.6122478 | 1.4785146 | 1.8759271 | up |
| MT1P3 | metallothionein 1 pseudogene 3 | 1.5198572 | 1.307409 | 1.7234105 | up |
| CSH2 | chorionic somatomammotropin hormone 2 | 1.5099572 | # | 1.3089397 | up |
| KRTAP10-2 | keratin associated protein 10-2 | 1.5006515 | # | 1.2620568 | up |
| MT1JP|MT1M | metallothionein 1J (pseudogene) | metallothionein 1M |
1.4997663 | 1.2292569 | 1.8385758 | up |
| MT1P2 | metallothionein 1 pseudogene 2 | 1.4846494 | 1.2776792 | # | up |
| MT1H | metallothionein 1H | 1.4614742 | # | 2.0551221 | up |
| SCXA|SCXB | scleraxis homolog A | scleraxis homolog B | 1.4582701 | # | 1.2557648 | up |
| SCXA|SCXB | scleraxis homolog A | scleraxis homolog B | 1.4572202 | # | 1.25512 | up |
| TMEM61 | transmembrane protein 61 | 1.4298121 | # | # | up |
| MT1DP | metallothionein 1D (pseudogene) | 1.4165779 | 1.2316265 | # | up |
| GBP2 | guanylate binding protein 2, interferon inducible |
-1.5112702 | -1.4250351 | -1.4131097 | down |
| MIR21 | microRNA 21 | -1.5275458 | -1.2404983 | -1.6964701 | down |
| ZNF224 | zinc finger protein 224 | -1.572604 | -1.2397038 | -1.3674877 | down |
| SAA4 | serum amyloid A4, constitutive | -1.573077 | -1.3437153 | -1.5190501 | down |
| ACTR3C | ARP3 actin-related protein 3 homolog C (yeast) |
-1.5773983 | -1.2445956 | # | down |
| SNORD50B | small nucleolar RNA, C/D box 50B | -1.5776544 | # | -1.527359 | down |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -1.6224118 | -1.2303989 | -1.5386964 | down |
| CD109 | -1.659105 | # | -1.5179392 | down | |
| CYP3A7 | cytochrome P450, family 3 subfamily A, polypeptide 7 |
-1.664616 | -1.3983974 | -1.483224 | down |
| NT5E | 5ʹ-nucleotidase, ecto (CD73) | -1.691666 | -1.5449091 | -1.5966983 | down |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -1.700486 | -1.39644 | -1.4552168 | down |
| SNORD14E | small nucleolar RNA, C/D box 14E | -1.7864679 | # | -1.8290889 | down |
| SNORD75 | small nucleolar RNA, C/D box 75 | -1.8150924 | # | -1.5868542 | down |
| UCA1 | urothelial cancer associated 1 (non-protein coding) |
-1.8260639 | -1.5522093 | -1.6103948 | down |
| MIR15A | microRNA 15a | -1.9946613 | -1.3650888 | -1.779063 | down |