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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Aug 24;288(3):399–408. doi: 10.1016/j.taap.2015.08.011

Table 2.

Top fifteen up- and downregulated genes (p<0.05) by 24 hour treatment with 0.5 μM CdCl2 in HepG2 cells. Fold changes for the other treatments also listed. # fold change >1.25

Gene Symbol Gene Description Fold Change
(0.5 μM)
Fold Change
(0.1 μM)
Fold Change
(1.0 μM)
Regulation
MT1G metallothionein 1G 2.215775 1.5027326 2.6238236 up
MT1F metallothionein 1F 1.9121428 1.405878 2.2424114 up
MT1M metallothionein 1M 1.8444134 # 6.988504 up
MT1B metallothionein 1B 1.7858652 # 5.00817 up
MT1X metallothionein 1X 1.6122478 1.4785146 1.8759271 up
MT1P3 metallothionein 1 pseudogene 3 1.5198572 1.307409 1.7234105 up
CSH2 chorionic somatomammotropin hormone 2 1.5099572 # 1.3089397 up
KRTAP10-2 keratin associated protein 10-2 1.5006515 # 1.2620568 up
MT1JP|MT1M metallothionein 1J (pseudogene) |
metallothionein 1M
1.4997663 1.2292569 1.8385758 up
MT1P2 metallothionein 1 pseudogene 2 1.4846494 1.2776792 # up
MT1H metallothionein 1H 1.4614742 # 2.0551221 up
SCXA|SCXB scleraxis homolog A | scleraxis homolog B 1.4582701 # 1.2557648 up
SCXA|SCXB scleraxis homolog A | scleraxis homolog B 1.4572202 # 1.25512 up
TMEM61 transmembrane protein 61 1.4298121 # # up
MT1DP metallothionein 1D (pseudogene) 1.4165779 1.2316265 # up
GBP2 guanylate binding protein 2, interferon
inducible
-1.5112702 -1.4250351 -1.4131097 down
MIR21 microRNA 21 -1.5275458 -1.2404983 -1.6964701 down
ZNF224 zinc finger protein 224 -1.572604 -1.2397038 -1.3674877 down
SAA4 serum amyloid A4, constitutive -1.573077 -1.3437153 -1.5190501 down
ACTR3C ARP3 actin-related protein 3 homolog C
(yeast)
-1.5773983 -1.2445956 # down
SNORD50B small nucleolar RNA, C/D box 50B -1.5776544 # -1.527359 down
TRA2A transformer 2 alpha homolog (Drosophila) -1.6224118 -1.2303989 -1.5386964 down
CD109 -1.659105 # -1.5179392 down
CYP3A7 cytochrome P450, family 3 subfamily A,
polypeptide 7
-1.664616 -1.3983974 -1.483224 down
NT5E 5ʹ-nucleotidase, ecto (CD73) -1.691666 -1.5449091 -1.5966983 down
SPINK1 serine peptidase inhibitor, Kazal type 1 -1.700486 -1.39644 -1.4552168 down
SNORD14E small nucleolar RNA, C/D box 14E -1.7864679 # -1.8290889 down
SNORD75 small nucleolar RNA, C/D box 75 -1.8150924 # -1.5868542 down
UCA1 urothelial cancer associated 1 (non-protein
coding)
-1.8260639 -1.5522093 -1.6103948 down
MIR15A microRNA 15a -1.9946613 -1.3650888 -1.779063 down