Table 3.
Top fifteen up- and downregulated genes (p<0.05) by three week treatment with 0.1 μM CdCl2 in HepG2 cells. Fold changes for other treatments are also listed. ## fold change <1.25
| Gene Symbol | Gene Description | Fold Change (0.1 μM) |
Fold Change (0.05 μM) |
Fold Change (0.01 μM) |
Regulation |
|---|---|---|---|---|---|
| GSTTP1| GSTTP2| |
glutathione S-transferase theta pseudogene 1 |
1.72073 | 1.4901183 | 1.379154 | up |
| SNRPN | small nuclear ribonucleoprotein polypeptide N |
1.6563919 | 1.6350169 | ## | up |
| CYP3A7 | cytochrome P450, family 3, subfamily A, polypeptide 7 |
1.5384295 | 1.3135703 | ## | up |
| NPNT | NPNT nephronectin | 1.5199842 | 1.4056195 | ## | up |
| CAB39L | calcium binding protein 39-like | 1.5002468 | 1.240774 | ## | up |
| ZBTB38 | zinc finger and BTB domain containing 38 | 1.4971563 | 1.3198949 | ## | up |
| SNORD116-13 | Small Nucleolar RNA, C/D Box 116-13 | 1.4758297 | 1.2465166 | 1.2062092 | up |
| FBLN5 | fibulin 5 | 1.4431939 | 1.4760754 | 1.3243747 | up |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 |
1.4407821 | 1.4589071 | 1.2065107 | up |
| C6orf138 | chromosome 6 open reading frame 138 | 1.4336088 | 1.3983722 | ## | up |
| C5orf41 | CREB3 regulatory factor | 1.422349 | 1.3452742 | ## | up |
| MGAM | maltase-glucoamylase (alpha-glucosidase) | 1.4202621 | 1.3677275 | ## | up |
| SNORD109A| SNORD109B |
small nucleolar RNA, C/D box 109A/109B | 1.4162974 | 1.3215218 | 1.3739192 | up |
| SNORD109A| SNORD109B |
small nucleolar RNA, C/D box 109A/109B | 1.4149537 | 1.3213891 | 1.3719118 | up |
| SCARNA9L | small Cajal body-specific RNA 9-like | 1.4086239 | 1.220644 | 1.3410316 | up |
| RRM2 | ribonucleotide reductase M2 | −1.4714146 | −1.3555955 | ## | down |
| BTBD11 | BTB (POZ) domain containing 11 | −1.4720253 | −1.4257193 | ## | down |
| CTGF | connective tissue growth factor | −1.4752284 | −1.3320917 | ## | down |
| HIST1H3B | histone cluster 1, H3b | −1.485579 | −1.3974302 | ## | down |
| EGR1 | early growth response 1 | −1.517825 | −1.4408088 | ## | down |
| TGM2 | transglutaminase 2 | −1.5214871 | −1.4627025 | ## | down |
| ANKRD1 | ankyrin repeat domain 1 | −1.5234282 | −1.4508984 | ## | down |
| HIST1H2AK| HIST1H2BN |
histone cluster 1, H2ak/H2bn | −1.537931 | ## | ## | down |
| MIXL1 | Mix paired-like homeobox | −1.5498296 | −1.3671521 | ## | down |
| SLC16A6 | solute carrier family 16, member 6 | −1.5749238 | −1.6012409 | −1.322911 | down |
| SLC2A3 | solute carrier family 2 member 3 | −1.5907145 | −1.4265127 | ## | down |
| ADH4 | alcohol dehydrogenase 4 (class II) | −1.6070219 | −1.3255012 | −1.2636199 | down |
| LOC1720 | dihydrofolate reductase pseudogene | −1.632394 | −1.3695079 | −1.207613 | down |
| ID1 | inhibitor of DNA binding 1 | −1.6802144 | −1.5311089 | ## | down |
| C8orf4 | chromosome 8 open reading frame 4 | −1.7252662 | −1.5806782 | ## | down |