Table 2.
Effect of sulfonylurea derivatives on blood glucose levels in NIDDM induced rats.
| Compounds | R/R′ | Blood glucose level (mg/dl) in STZ rats |
Percent inhibition in the rise of blood glucose level in STZ rats | |
|---|---|---|---|---|
| On fasting condition | After 90 min of fed | |||
| Control | – | 79.3 ± 3.4 | 116.2 ± 2.5 | – |
| Standard (Glibenclamide) | – | 78.7 ± 2.4 | 74.1 ± 4.8 | 112.4 |
| 5a | C6H5/H | 76.5 ± 3.7 | 82.3 ± 4.6 | 84.3 |
| 5b | C6H5/Cl | 72.3 ± 3.6 | 80.7 ± 2.9 | 77.3 |
| 5c | C6H5/OH | 73.6 ± 5.6 | 80.2 ± 3.8 | 82.1 |
| 5d | C6H5/NO2 | 77.4 ± 3.1 | 81.4 ± 2.4 | 89.2 |
| 5e | C6H5/OCH3 | 74.3 ± 4.7 | 83.9 ± 4.7 | 73.9 |
| 5f | 4-NO2C6H4/H | 78.5 ± 4.6 | 83.1 ± 5.1 | 87.5 |
| 5g | 4-NO2C6H4/Cl | 76.3 ± 3.4 | 82.4 ± 4.8 | 83.5 |
| 5h | 4-NO2C6H4/OH | 79.4 ± 5.4 | 86.4 ± 4.7 | 77.8 |
| 5i | 4-NO2C6H4/NO2 | 78.7 ± 3.8 | 82.0 ± 3.6 | 91.1 |
| 5j | 4-NO2C6H4/OCH3 | 77.2 ± 2.8 | 83.5 ± 5.1 | 83.0 |
| 5k | Pyridin-2yl/H | 78.2 ± 2.7 | 83.2 ± 4.7 | 89.7 |
| 5l | Pyridin-2yl/Cl | 74.7 ± 3.6 | 81.7 ± 4.5 | 81.0 |
| 5m | Pyridin-2yl/OH | 76.4 ± 4.2 | 83.9 ± 5.7 | 79.7 |
| 5n | Pyridin-2yl/NO2 | 76.2 ± 2.8 | 82.1 ± 5.3 | 84.0 |
| 5o | Pyridin-2yl/OCH3 | 74.2 ± 4.8 | 82.3 ± 5.5 | 78.1 |
Data are expressed as value of mean ± SEM, n = 6. The noninsulin dependent diabetes (NIDDM) was induced by streptozotocin (STZ) at 40 mg/kg body weight by i.p. injection.