Table 1.

Details of experiments performed along with outcomes during optimization of SNEDDS preconcentrate by a central composite design.

Std. order	Run order	X1	X2	X3	X1	X2	X3	Y1		Y2		Y3
By parts (w/w)			By percentage (w/w)			Obs.a	Pred.b	Obs.a	Pred. b	Obs.a	Pred.b
8	1	60.00	60.00	30.00	40.00	40.00	20.00	47.8	30.5	24.3	4.8	99.3	100.8
7	2	20.00	60.00	30.00	18.18	54.54	27.27	42.9	61.3	10.5	22.0	99	95.5
18	3	40.00	40.00	20.00	40.00	40.00	20.00	45.4	48.0	12.2	22.7	99	98.5
10	4	73.63	40.00	20.00	55.10	29.93	14.96	121.1	123.3	175.8	172.8	81	81.3
16	5	40.00	40.00	20.00	40.00	40.00	20.00	49.1	48.0	27.6	22.7	98.2	98.5
4	6	60.00	60.00	10.00	46.15	46.15	7.69	76.6	90.9	112.8	136.3	96.2	93.9
14	7	40.00	40.00	36.81	34.24	34.24	31.51	58.6	55.9	45.8	57.1	97.8	99.5
11	8	40.00	6.364	20.00	60.27	9.58	30.13	158.4	156.9	190.5	186.4	78	78.6
3	9	20.00	60.00	10.00	22.22	66.66	11.11	35.6	18.3	7.5	1.1	99.3	101.4
6	10	60.00	20.00	30.00	54.54	18.18	27.27	105.2	122.7	162.0	173.3	84.8	81.6
17	11	40.00	40.00	20.00	40.00	40.00	20.00	46.5	48.0	19.2	22.7	98.3	98.5
1	12	20.00	20.00	10.00	40.00	40.00	20.00	47.1	64.5	22.5	46.9	98	95.4
12	13	40.00	73.63	20.00	29.93	55.10	14.96	39.5	40.5	9.4	6.2	99	99.7
15	14	40.00	40.00	20.00	40.00	40.00	20.00	49.7	48.0	29.5	22.7	98.7	98.5
20	15	40.00	40.00	20.00	40.00	40.00	20.00	45.8	48.0	14.2	22.7	98.9	98.5
5	16	20.00	20.00	30.00	28.57	28.57	42.85	84.7	70.5	121.8	103.3	95.9	97.1
19	17	40.00	40.00	20.00	40.00	40.00	20.00	51.9	48.0	32.8	22.7	98.7	98.5
9	18	6.36	40.00	20.00	9.58	60.27	30.13	20.9	18.3	4.6	0.3	99.9	100.5
13	19	40.00	40.00	3.18	48.08	48.08	3.82	99.4	101.6	138.7	120.2	92.8	92.4
2	20	60.00	20.00	10.00	66.66	22.22	11.11	238.4	220.1	275.8	269.2	64.8	67.2

X1, Captex 355; X2, Solutol HS 15; X3, Imwitor 988; Y1, mean droplet size (nm); Y2, turbidity (NTU) and Y3, percentage transmittance.

^aObserved.

^bPredicted.