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. 2015 Sep;12(5):528–539. doi: 10.11909/j.issn.1671-5411.2015.05.013

Figure 2. Dexamethasone down-regulates DHFR expression.

Figure 2.

(A): EA.hy 926 endothelial cells were treated with either Dex (1, 10 or 100 nmol/L) or with the solvent control DMSO for 24, 48 or 72 h. mRNA expression of DHFR was analyzed with qPCR; (B & C): protein expression was studied with Western blot analyses. GAPDH was shown for normalization. Columns represent mean ± SE, n = 12–24. *P < 0.05, **P < 0.01 compared with Ctl. Ctl: control; Dex: dexamethasone; DHFR: dihydrofolate reductase; NS: not significant.