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Mean relative change from baseline to 12 months (with 95 % CI) in a uCTX, b serum TRAP 5b, c serum P1NP, and d serum BALP. BALP bone-specific alkaline phosphatase, CI confidence interval, IV intravenous, P1NP procollagen type 1N-terminal propeptide, TRAP 5b tartrate-resistant acid phosphatase 5b, uCTX creatinine-corrected urinary collagen type 1 cross-linked C-telopeptide
