Table 2.
Univariate analysis of association of covariates with a fatal outcome
| Covariate | N | OR | 95% CI | P |
|---|---|---|---|---|
| Age (months) | 139 | 0.983 | 0.964–1.002 | 0.083 |
| Sex (male/female) | 139 | 0.862 | 0.365–2.029 | 0.733 |
| Prothrombin time (s) | 67 | 1.126 | 0.970–1.306 | 0.118 |
| Fibrin monomers (μg mL−1) | 114 | 1.003 | 0.996–1.010 | 0.422 |
| Fibrin degradation products (μg mL−1) | 74 | 1.013 | 1.001–1.025 | 0.035 |
| d‐dimers (μg mL−1) | 102 | 1.039 | 0.967–1.117 | 0.292 |
| Fibrinogen (g L−1) | 67 | 0.997 | 0.993–1.001 | 0.167 |
| Thrombin–antithrombin complexes (μg L−1) | 74 | 1.016 | 1.003–1.027 | 0.010 |
| Antithrombin activity (%) | 66 | 0.969 | 0.927–1.014 | 0.149 |
| Protein C activity (%) | 65 | 1.000 | 0.967–1.036 | 0.967 |
| Platelets (× 106 L−1) | 129 | 1.000 | 1.000–1.000 | 0.925 |
| Overt DIC (yes/no) | 98 | 3.068 | 1.085–8.609 | 0.035 |
| DIC score | 55 | 1.384 | 1.041–1.841 | 0.025 |
| Thrombomodulin (ng mL−1) | 115 | 1.091 | 1.029–1.158 | 0.004 |
| Lactate (mmol L−1) | 140 | 1.174 | 1.061–1.300 | 0.002 |
| Histidine‐rich protein‐2 (ng mL−1) | 51 | 1.001 | 0.999–1.003 | 0.496 |
| Parasitemia (parasites μL−1) | 136 | 1.000 | 1.000–1.000 | 0.835 |
| Hemoglobin (g dL−1) | 137 | 0.947 | 0.761–1.178 | 0.625 |
| Blood glucose (mmol L−1) | 140 | 1.138 | 1.000–1.295 | 0.049 |
CI, confidence interval; DIC, disseminated intravascular coagulation; OR, odds ratio. The OR indicates the estimated increase in the log odds of a fatal outcome per unit increase (e.g. thrombomodulin, each ng mL−1; lactate, each mmol L−1) for each continuous variable.