Figure 1.

Pathological changes in peripheral nerves of L31 mice after disease onset. Immune cell infiltration was revealed by immunohistochemistry analysis using antibodies against CD8 and Iba-1 (macrophages), while demyelination and axonal damage were detected with antibodies against PGP9.5 and fluoromyelin, respectively. (A) Only few resident macrophages and no CD8⁺ T cells were detected in sciatic nerves of wild type (WT); there were massive infiltration of Iba-1⁺ macrophages and CD8⁺ T cells as well as severe demyelination and axonal damage in sciatic (B), facial (C), and trigeminal nerves (D) of symptomatic L31 mice (L31). Scale bar: 50 μm.