Figure 1.

(A) Receptors and ligand involved in NK cell-mediated cytotoxicity. (B) Percentage of long-term CR patients after NK cell infusion. Thirteen AML patients, five with active disease, two in molecular relapse, and six in morphological complete remission (CR) were treated with alloreactive NK cells, after fludarabine/cyclophosphamide immunosuppressive chemotherapy. Only one of the five patients with active disease achieved transient CR, whereas the other four patients had no clinical benefit. On the contrary, five out of eight patients showed a response, which in some cases was long-lasting CR [adapted from Curti et al. (5)].