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Trafficking of PLP1 gene products through the secretory pathway of transfected cells. Schematics of PLP1 (top left) and DM-20 (top right) illustrating topology, sites of missense mutation relevant to the current study, and location of the PLP1-specific peptide. Confocal extended-focus series through transfected COS-7 cells labeled with antibodies against PLP1 (green in a,c,e,g) or DM-20 (green in b,d,f,h) and the lysosomal marker LAMP2 (red).
