[Table/Fig-3]:
Haematological and molecular characterization of HPFH-3 cases
| Parameters | IB | IIA | IIB | IIIA | IIIB | IIIC | IIID | IIIE | IIIF |
| Age (in years) | 73 | 50 | 43 | 26 | 24 | 22 | 18 | 15 | 12 |
| Relationship | GM | F | M | D1 | D2 | D3 | D4 | D5 | S1 |
| Haemoglobin fraction by HPLC | |||||||||
| HbA0 (%) | 65.9 | 67.4 | 87.9 | 88.9 | 88.3 | 61.3 | 65 | 86.9 | 61.7 |
| HbA2 (%) | 2.0 | 2.3 | 3.1 | 2.7 | 2.8 | 2.1 | 2.2 | 2.7 | 2.3 |
| HbF (%) | 25.2 | 21.8 | 0.4 | 0.4 | 0.3 | 30.5 | 25.4 | 1.0 | 27.7 |
| Red cell indices | |||||||||
| WBC (103/μL) | 7.6 | 5.6 | 4.2 | 6.5 | 8.1 | 7.9 | 7.8 | 7.1 | 6.8 |
| RBC (106/μL) | 4.69 | 6.10 | 3.33 | 4.19 | 3.33 | 5.55 | 4.92 | 5.72 | 5.64 |
| Haemoglobin (g/dL) | 9.8 | 15 | 11.8 | 12.5 | 13.7 | 14.1 | 12.9 | 12.2 | 13.3 |
| HCT (%) | 35.1 | 48.3 | 32 | 37.9 | 29 | 43.7 | 38.5 | 40.3 | 41.4 |
| Platelets (103/μL) | 172 | 266 | 236 | 249 | 222 | 278 | 168 | 283 | 183 |
| MCV (fL) | 79.8 | 79.2 | 70.2 | 90.5 | 72.6 | 78.7 | 78 | 70 | 76.4 |
| MCH (pg) | 26.2 | 24.6 | 22.2 | 30.1 | 23.6 | 25.4 | 26.1 | 21.3 | 23.6 |
| MCHC (g/dL) | 31.4 | 31.1 | 31.6 | 33.2 | 28.9 | 32.3 | 33.4 | 30.2 | 32.1 |
| Other Investigations | |||||||||
| Reticulocyte count (%) | 0.34 | 0.86 | 0.74 | 0.54 | 0.48 | 0.84 | 0.72 | 1.03 | 0.76 |
| Distribution of HbF | Pan | Pan | - | - | - | Pan | Pan | - | Pan |
| Alpha thalassemia | αα/αα | αα/αα | -3.7α/αα | αα/αα | -3.7α/αα | αα/αα | αα/αα | -3.7α/αα | αα/αα |
| HPFH-3 | A/HPFH | A/HPFH | A/A | A/A | A/A | A/HPFH | A/HPFH | A/A | A/HPFH |
*WBC, white blood cells; RBC, Red blood cells; HCT, Haematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular Hb; MCHC, mean corpuscular Hb concentration; Pan–pancellular; GM, Grandmother; F, father; M, mother, D, daughter; S, Son. HPFH, High persistence of foetal haemoglobin