Table 2. Distribution of Genotypes and Allele Frequencies of IL-10 (A-1082 G) Promoter Polymorphism in Breast Cancer Patients and Controls.
| Genotype | Disease N = 125 | Control N = 160 | χ2 | P Value | OR (95% CI) | |
|---|---|---|---|---|---|---|
| Co-dominant | ||||||
| AA | 76 (60.8) | 67 (41.875) | ref | |||
| AG | 31 (24.8) | 78 (48.75) | 14.46 | 0.00014 a | 2.854 (1.68 - 4.849) | |
| GG | 18 (14.4) | 15 (9.375) | 0.002342 | 0.9614 | 0.945 (0.4422 - 2.021) | |
| Allele | ||||||
| A | 183 (73.2) | 212 (66.25) | ||||
| G | 67 (26.8) | 108 (33.75) | 2.868 | 0.0903 | 1.391 (0.967 - 2.001) | |
| Dominant | ||||||
| AA | 76 (60.8) | 67 (41.875) | ||||
| AG + GG | 49 (39.2) | 93 (58.125) | 9.311 | 0.0022 a | 2.153 (1.336 - 3.469) | |
| Recessive | ||||||
| AA + AG | 107 (85.6) | 145 (90.625) | ||||
| GG | 18 (14.4) | 15 (9.375) | 1.275 | 0.2598 | 0.615 (0.2966 -1.275) | |
| Over dominant | ||||||
| AA + GG | 94 (75.2) | 82 (51.25) | ||||
| AG | 31 (24.8) | 78 (48.75) | 16.04 | 0.00006 a | 2.884 (1.731- 4.807) |
a P ≤ 0.05.