Table 3. Distribution of Genotypes and Allele Frequencies of IL-10 (A -1082 G) Promoter Polymorphism With Respect to Early Stage and Late Stage Breast Cancer.
| Genotype | Early Stage Breast Cancer | Late Stage Breast Cancer | ||||||
|---|---|---|---|---|---|---|---|---|
| Disease (N = 46) | Control (N = 160) | P Value χ2 | OR (95% CI) | Disease (N = 52) | Control (N = 160) | P Value χ2 | OR (95% CI) | |
| Co-Dominant | ||||||||
| AA | 28 (60.86) | 67 (41.87) | 33 (63.46) | 67 (41.87) | ||||
| AG | 13 (28.26) | 78 (48.75) | 0.02029 a | 2.507 (1.203 - 5.226) | 11 (21.15) | 78 (48.75) | 0.0014 a | 3.493 (1.639 -7.441) |
| GG | 5 (10.86) | 15 (9.375) | 0.896 | 1.254 (0.415- 3.781) | 8 (15.38) | 15 (9.375) | 0.9348 | 0.9235 (0.355 -2.397) |
| Allele | ||||||||
| A | 69 (75.0) | 212 (66.25) | 77 (74.03) | 212 (66.25) | ||||
| G | 23 (25.0) | 108 (33.75) | 0.144 | 1.528 (0.903 - 2.585) | 27 (25.96) | 108 (33.75) | 0.174 | 1.453 (0.884 -2.385) |
| Dominant | ||||||||
| AA | 28 (60.86) | 67 (41.87) | 33 (63.46) | 67 (41.87) | ||||
| AG + GG | 18 (39.13) | 93 (58.12) | 0.03488 a | 2.159 (1.105 -4.221) | 19 (36.53) | 93 (58.12) | 0.0108 a | 2.411 (1.264 -4.599) |
| Recessive | ||||||||
| AA + AG | 41 (89.13) | 145 (90.62) | 44 (84.61) | 145 (90.62) | ||||
| GG | 5 (10.86) | 15 (9.375) | 0.9847 | 0.848 (0.291-2.473) | 8 (15.38) | 15 (9.37) | 0.569 (0.226 -1.43) | |
| Over Dominant | ||||||||
| AA + GG | 33 (71.74) | 82 (51.25) | 41 (78.84) | 82 (51.25) | ||||
| AG | 13 (28.26) | 78 (48.75) | 0.02158 a | 2.415(1.184 -4.925) | 11 (21.15) | 78 (48.75) | 0.0008 a | 3.545(1.702 -7.388) |
a P ≤ 0.05.