Table 4. Distribution of Genotypes and Allele Frequencies of IL-10 (A-1082 G) Promoter Polymorphism in Breast Cancer Patients with Age at Onset < 40 and > 40 Years and Age Matched Controls.
| Genotype | Age at Onset < 40 | Age at Onset > 40 | ||||||
|---|---|---|---|---|---|---|---|---|
| Disease (N = 46) | Control (N = 160) | P Value χ2 | OR (95% CI) | Disease (N = 52) | Control (N = 160) | P Value χ2 | OR (95% CI) | |
| Co-Dominant | ||||||||
| AA | 20 (58.82) | 14 (26.92) | 56 (61.53) | 50 (47.61) | ||||
| AG | 8 (23.52) | 34 (65.38) | 0.0008 a | 6.071 (2.169- 16.99) | 23 (25.27) | 44 (41.90) | 0.0262 | 2.143 (1.139 -4.032) |
| GG | 6 (17.64) | 4 (7.69) | 0.7647 | 0.9524 (0.226 - 4.01) | 12 (13.18) | 11 (10.47) | 0.8625 | 1.027 (0.416 -2.532) |
| Allele | ||||||||
| A | 48 (70.58) | 62 (59.61) | 135 (74.17) | 144 (68.57) | ||||
| G | 20 (29.41) | 42 (40.38) | 0.1928 | 1.626 (0.846 -3.121) | 47 (25.82) | 66 (31.42) | 0.2681 | 1.316 (0.846 -2.047) |
| Dominant | 56 (61.53) | 50 (47.61) | ||||||
| AA | 20 (58.82) | 14 (26.92) | 35 (38.46) | 55 (52.38) | 0.07084 b | 1.76 (0.995 -3.112) | ||
| AG + GG | 14 (41.17) | 38 (73.07) | 0.0062 a | 3.878 (1.549 - 9.706) | ||||
| Recessive | 79 (86.81) | 94 (89.52) | ||||||
| AA + AG | 28 (82.35) | 48 (92.30) | 12 (13.18) | 11 (10.47) | 0.7147 | 0.770 (0.322 -1.841) | ||
| GG | 6 (17.64) | 4 (7.69) | 0.2887 | 0.3889 (0.101 -1.497) | 56 (61.53) | 50 (47.61) | ||
| Over Dominant | ||||||||
| AA + GG | 26 (76.47) | 18 (34.61) | 68 (74.72) | 61 (58.09) | ||||
| AG | 8 (23.52) | 34 (65.38) | 0.0003 a | 6.139 (2.311 -16.31) | 23 (25.27) | 44 (41.90) | 0.02162 a | 2.133 (1.157 -3.93) |
a P ≤ 0.05.
b P ≥ 0.05 - < 0.10 (borderline significant).