Table 5. Distribution of Genotypes and Allele Frequencies of IL-10 (A-1082 G) Promoter Polymorphism in Premenopausal Breast Cancer Patients, Versus Premenopausal Controls and Postmenopausal Breast Cancer Patients Versus Postmenopausal Controls.
| Genotype | Premenopausal | Postmenopausal | ||||||
|---|---|---|---|---|---|---|---|---|
| Disease (N = 46) | Control (N = 160) | χ2 P Value | OR (95% CI) | Disease (N = 52 ) | Control (N = 160) | χ2 P Value | OR (95% CI) | |
| Co-Dominant | ||||||||
| AA | 16 (57.14) | 22 (29.33) | 60 (62.5) | 45 (52.94) | ||||
| AG | 7 (25) | 47 (62.66) | 0.0033 a | 4.883 (1.757 -13.57) | 23 (23.95) | 31 (36.47) | 0.116 | 1.797 (0.925 -3.489) |
| GG | 5 (17.85) | 6 (8) | 0.8821 | 0.8727 (0.226 -3.367) | 13 (13.54) | 9 (10.58) | 0.9449 | 0.923 (0.362 - 2.348) |
| Allele | ||||||||
| A | 39 (69.64) | 91 (60.66) | 143 (74.4) | 121 (71.17) | ||||
| G | 17 (30.35) | 59 (39.33) | 0.3069 | 1.487 (0.771 -2.869) | 49 (25.5) | 49 (28.82) | 0.557 | 1.182 (0.743 - 1.88) |
| Dominant | ||||||||
| AA | 16 (57.14) | 22 (29.33) | 60 (62.5) | 45 (52.94) | ||||
| AG + GG | 12 (42.85) | 53 (70.66) | 0.0176* | 3.212 (1.308 -7.888) | 36 (37.5) | 40 (47.06) | 0.2511 | 1.481 (0.818 -2.682) |
| Recessive | ||||||||
| AA + AG | 23 (82.14) | 69 (92) | 83 (86.45) | 76 (89.41) | ||||
| GG | 5 (17.8) | 6 (8) | 0.2803 | 0.4 (0.1115 -1.435) | 13 (13.54) | 9 (10.58) | 0.7047 | 0.756 (0.305 -1.869) |
| Over Dominant | ||||||||
| AA + GG | 21 (75) | 28 (37.33) | 73 (76.04) | 54 (63.52) | ||||
| AG | 7 (25) | 47 (62.66) | 10.14 | 0.0014 a | 23 (23.96) | 31 (36.47) | 0.0942 b | 1.82 (0.957 -3.469) |
a P ≤ 0.05.
b P ≥ 0.05 - < 0.10 (borderline significant).