Cell death as a function of treatment after 24 hours exposure to ropivacaine alone (RPV) and clonidine(C)-buprenorphine(B)-dexamethasone(D)-midazolam(MDZ) adjuvant combinations.
Panel A shows all RPV-M combinations. Panel B shows the cytotoxicity outcomes in clinical concentrations with and without RPV 2.5mg/mL.
Source: Figure 3A, Williams, BA, Hough, KA, Tsui BY et al. Neurotoxicity of Adjuvants Used in Perineural Anesthesia and Analgesia in Comparison with Ropivacaine. Reg Anesth Pain Med. 2011 May–Jun;36(3):225–230