Table 1.

Eligibility criteria for the ACTiMuS trial

Inclusion criteria	Exclusion criteria
Either sex, 18–65 years old	Pregnancy, breastfeeding or lactation
Diagnosis of clinically definite MS as defined by the McDonald criteria	History of autologous/allogeneic bone marrow transplantation or peripheral blood stem cell transplant
	Bone marrow insufficiency
MS disease severity EDSS 4–6	History of lymphoproliferative disease or previous total lymphoid irradiation
	Immune deficiency
Disease duration >5 years	History of current or recent (<5 years) malignancy
Disease progression (not attributable to relapse) in the year prior to entry	Chronic or frequent drug-resistant bacterial infections or presence of active infection requiring antimicrobial treatment
Signed, written informed consent	Frequent and/or serious viral infection
Willing and able to comply with study visits according to protocol for the full study period	Systemic or invasive fungal disease within 2 years of entry to study
	Significant renal, hepatic, cardiac or respiratory dysfunction
	Contraindication to anaesthesia
	Bleeding or clotting diathesis
	Current or recent (within preceding 12 months) immunomodulatory therapy other than corticosteroid therapy
	Treatment with corticosteroids within the preceding 3 months
	Significant relapse within preceding 6 months
	Predominantly relapsing-remitting disease over preceding 12 months
	Radiation exposure in the past year other than chest/dental x-rays
	Previous claustrophobia
	The presence of any implanted metal or other contraindication to MRI
	Participation in another experimental study or treatment within previous 24 months