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Ago2-target affinities
| t1 nucleotide | KD (nM) | |
|---|---|---|
| WT Ago2 | A481T-Ago2 | |
| A | 0.75 ± 0.04 | 1.5 ± 0.13 |
| G | 1.9 ± 0.09 | 1.8 ± 0.11 |
| U | 1.9 ± 0.10 | – |
| C | 1.8 ± 0.12 | – |
| DAP | 0.45 ± 0.03 | – |
| I | 1.7 ± 0.09 | – |
| m6A | 1.8 ± 0.12 | – |
Dissociation constants for wild-type (WT) and mutant Ago2 binding short target RNAs with different t1 nucleotides.
