Table 4.
Linear regression and generalized estimating equation models for effect of genetic risk estimate on change in perceived risk of cancer
| Breast | Prostate | Colorectal | Lungc | |
|---|---|---|---|---|
| Change in perceived risk: baseline to 2Wa | ||||
| Elevated risk result: LS mean (95 % CI) | 0.61 (0.42, 0.79) | 0.77 (0.58, 0.95) | 0.50 (0.41, 0.60) | 0.62 (0.49, 0.75) |
| Average risk result: LS mean (95 % CI) | −0.20 (−0.27, −0.14) | −0.21 (−0.31, −0.11) | −0.05 (−0.10, 0.01) | 0.18 (0.10, 0.27) |
| LS mean difference (95 % CI) | 0.81 (0.62, 1.00) | 0.97 (0.76, 1.19) | 0.55 (0.44, 0.66) | 0.44 (0.31, 0.57) |
| p-valueDifference | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Change in perceived risk: baseline to 6Ma | ||||
| Elevated risk result: LS mean (95 % CI) | 0.53 (0.32, 0.74) | 0.51 (0.32, 0.69) | 0.33 (0.24, 0.43) | 0.58 (0.44, 0.72) |
| Average risk result: LS mean (95 % CI) | −0.15 (−0.22, −0.07) | −0.14 (−0.24, −0.04) | −0.04 (−0.09, 0.02) | 0.22 (0.13, 0.31) |
| LS mean difference (95 % CI) | 0.68 (0.46, 0.90) | 0.65 (0.43, 0.86) | 0.37 (0.26, 0.48) | 0.36 (0.22, 0.49) |
| p-valueDifference | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| GEE Model: ΔPRb | ||||
| Elevated risk result: β ± SE (p-value) | 0.68 ± 0.29 (0.02) | 1.06 ± 0.20 (<0.0001) | 0.79 ± 0.11 (<0.0001) | 0.59 ± 0.13 (<0.0001) |
| Elevated risk result*survey: β ± SE (p-value) | 0.06 ± 0.19 (0.76) | −0.15 ± 0.11 (0.17) | −0.20 ± 0.07 (0.0027) | −0.11 ± 0.08 (0.17) |
2 W 2-week follow-up, 6 M 6-month follow-up, LS least squares adjusted, CI confidence interval, SE standard error
aAdjusted for baseline perceived risk, age, gender, race/ethnicity, education, and company
bAdjusted for baseline perceived risk, age, gender, race/ethnicity, education, and company, with result*survey interaction term
cMultivariate lung cancer analyses additionally adjusted for smoking status