Table 3.

Therapeutic strategies targeting macrophage function

Depletion of macrophages	Clodronate Nitric oxide donors Mammalian target of rapamycin inhibitors Protein synthesis inhibitors Statins
Reduction of macrophage recruitment/retention	Prodrug of dexamethasone VCAM-1 inhibitors (e.g. AGI-1067, CAM741) Notch1 TRAF1 TSP-1
Suppression of proinflammatory capabilities	Induction of M2 ( IL-4, M-CSF) IL-1β inhibition ( e.g. Canakinumab) Prevention of oxidative damage (e.g. GSH) Resetting efferocytosis ( e.g. IL-10, LXR agonists) Notch inhibitors