Table 2.
Interaction between SNPs and well arsenic over the course of follow-up in relation to systolic blood pressure.
| Gene | db SNP ID | MAF (%) |
Genetic modela |
Arsenic*Timeb
(95% CI) |
SNP*Timec
(95% CI) |
Arsenic*SNP*Timed
(95% CI) |
p-valuee | q-valuef |
|---|---|---|---|---|---|---|---|---|
| APOE | rs429358 | 9.6 | Dominant | 0.17 (0.02, 0.32) | −0.35 (−0.90, 0.19) | 0.26 (−0.08, 0.59) | 0.14 | 0.78 |
| Recessive | 0.20 (0.06, 0.34) | −0.91 (−3.23, 1.42) | 2.05 (0.57, 3.54) | 0.01 | 0.34 | |||
|
| ||||||||
| CBS | rs234709 | 17.7 | Dominant | 0.10 (−0.08, 0.27) | −0.52 (−0.98, −0.07) | 0.34 (0.06, 0.62) | 0.02 | 0.54 |
| Recessive | 0.20 (0.05, 0.36) | −0.75 (−2.21, 0.71) | 0.49 (−1.00, 1.97) | 0.52 | 0.94 | |||
| rs2014564 | 47.6 | Dominant | 0.02 (−0.22, 0.27) | −0.21 (−0.69, 0.27) | 0.28 (0.01, 0.56) | 0.04 | 0.67 | |
| Recessive | 0.18 (0.02, 0.34) | −0.06 (−0.58, 0.46) | 0.17 (−0.12, 0.46) | 0.25 | 0.86 | |||
| rs2124459 | 18.3 | Dominant | 0.12 (−0.06, 0.30) | −0.51 (−0.98, −0.04) | 0.40 (0.12, 0.68) | 0.01 | 0.34 | |
| Recessive | 0.24 (0.09, 0.40) | −0.62 (−2.19, 0.95) | 0.41 (−1.12, 1.95) | 0.60 | 0.96 | |||
| rs234701 | 47.1 | Dominant | 0.02 (−0.23, 0.26) | −0.26 (−0.73, 0.21) | 0.29 (0.02, 0.57) | 0.04 | 0.67 | |
| Recessive | 0.20 (0.04, 0.36) | 0.00 (−0.52, 0.52) | 0.12 (−0.18, 0.41) | 0.44 | 0.93 | |||
|
| ||||||||
| CYBA | rs3794624 | 10.9 | Dominant | 0.22 (0.07, 0.38) | −0.10 (−0.61, 0.41) | 0.02 (−0.29, 0.33) | 0.90 | 0.99 |
| Recessive | 0.22 (0.07, 0.36) | −0.67 (−2.41, 1.09) | 2.43 (0.78, 4.08) | 0.004 | 0.34 | |||
|
| ||||||||
| GSTM1 | rs4147567 | 4.0 | Dominant | 0.16 (0.02, 0.32) | −0.69 (−1.50, 0.12) | 0.60 (0.17, 1.03) | 0.01 | 0.34 |
|
| ||||||||
| GSTP1 | rs749174 | 18.0 | Dominant | 0.13 (−0.04, 0.30) | −0.45 (−0.89, 0.00) | 0.29 (0.02, 0.52) | 0.04 | 0.67 |
| Recessive | 0.22 (0.07, 0.37) | −0.70 (−2.19, 0.79) | 0.43 (−1.11, 1.97) | 0.58 | 0.96 | |||
|
| ||||||||
| GSTT1 | rs4630 | 7.1 | Dominant | 0.25 (0.09, 0.41) | −0.34 (−1.14, 0.46) | 0.10 (−0.33, 0.52) | 0.66 | 0.98 |
| Recessive | 0.24 (0.09, 0.39) | −0.91 (−2.19, 0.38) | 1.07 (0.11, 2.03) | 0.03 | 0.67 | |||
|
| ||||||||
| IL6 | rs1524107 | 20.4 | Dominant | 0.09 (−0.08, 0.27) | −0.34 (−0.76, 0.09) | 0.34 (0.08, 0.60) | 0.01 | 0.47 |
| Recessive | 0.22 (0.07, 0.36) | 0.54 (−0.76, 1.83) | 0.10 (−0.81, 1.01) | 0.83 | 0.98 | |||
|
| ||||||||
| NOS3 | rs743506 | 17.3 | Dominant | 0.26 (0.09, 0.42) | 0.11 (−0.33, 0.55) | −0.10 (−0.36, 0.16) | 0.45 | 0.93 |
| Recessive | 0.20 (0.05, 0.34) | −0.97 (−2.04, 0.10) | 0.72 (0.04, 1.40) | 0.04 | 0.67 | |||
|
| ||||||||
| S1PR1 | rs3753194 | 30.6 | Dominant | 0.24 (0.04, 0.45) | 0.07 (−0.35, 0.49) | −0.04 (−0.29, 0.22) | 0.78 | 0.98 |
| Recessive | −0.19 (−0.60, 0.23) | −0.90 (−1.65, −0.15) | 0.45 (0.02, 0.88) | 0.04 | 0.67 | |||
|
| ||||||||
| SOD2 | rs5746123 | 11.8 | Dominant | 0.15 (0.00, 0.31) | −0.02 (−0.52, 0.48) | 0.33 (0.02, 0.64) | 0.04 | 0.67 |
| Recessive | 0.22 (0.07, 0.36) | 0.27 (−1.22, 1.77) | 0.18 (−0.75, 1.12) | 0.70 | 0.98 | |||
Abbreviations: SNPs, single nucleotide polymorphisms; CI, confidence interval; SBP, systolic blood pressure.
Recessive models are not shown for variants where fewer than 10 individuals possessed the homozygous recessive genotype
Coefficient in relation to interaction between well arsenic level and time
Coefficient in relation to interaction between each SNP in the dominant or recessive genetic models and time.
Coefficient in relation to the three-way interaction between each SNP, time and well arsenic in the dominant, or recessive genetic models.
P values for interaction adjusted for sex, age at enrollment, body mass index, smoking status (never, past, and current), educational attainment and diabetes at baseline, prior to FDR correction for multiple comparisons.
Q values are adjusted P values for interaction adjusted for sex, age at enrollment, body mass index, smoking status (never, past, and current), educational attainment and diabetes at baseline, after FDR correction for multiple comparisons.