Skip to main content
. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jul 26;288(1):95–105. doi: 10.1016/j.taap.2015.07.017

Table 4.

Interaction between SNPs and well arsenic over the course of follow-up in relation to pulse pressure.

Gene db SNP ID MAF
(%)		 Genetic
modela 		Arsenic*Timeb
(95% CI)		 SNP*Timec
(95% CI)		 Arsenic*SNP*Timed
(95% CI)		 p-valuee q-valuef
APOE rs429358 9.6 Dominant 0.10 (−0.01, 0.20) −0.39 (−0.77, −0.02) 0.22 (−0.01, 0.44) 0.06 0.62
Recessive 0.12 (0.02, 0.22) −1.77 (−3.38, −0.16) 1.08 (0.11, 2.06) 0.03 0.52
AS3MT rs4290163 8.1 Dominant 0.18 (0.07, 0.28) −0.14 (−0.56, 0.27) 0.34 (0.10, 0.58) 0.01 0.45
Recessive 0.14 (0.03, 0.24) 0.24 (−1.41, 1.89) −0.30 (−1.39, 0.78) 0.58 0.90
rs10509761 28.8 Dominant 0.07 (−0.07, 0.21) −0.01 (−0.30, 0.28) 0.11 (−0.05, 0.28) 0.18 0.79
Recessive 0.10 (−0.01, 0.21) −0.14 (−0.66, 0.37) 0.32 (0.06, 0.58) 0.02 0.49
CBS rs6586281 45.0 Dominant 0.29 (0.14, 0.44) −0.33 (−0.64, 0.02) 0.23 (0.05, 0.40) 0.01 0.46
Recessive 0.15 (0.04, 0.26) −0.04 (−0.39, 0.31) −0.10 (−0.31, 0.12) 0.38 0.88
rs234701 47.1 Dominant −0.01 (−0.17, 0.15) −0.37 (−0.70, −0.04) 0.21 (0.03, 0.39) 0.02 0.49
Recessive 0.13 (0.01, 0.24) −0.15 (−0.51, 0.22) 0.06 (−0.13, 0.25) 0.54 0.90
rs706208 49.3 Dominant 0.26 (0.09, 0.44) −0.25 (−0.59, 0.09) 0.19 (0.01, 0.38) 0.04 0.57
Recessive 0.13 (0.02, 0.25) 0.14 (−0.22, 0.50) −0.06 (−0.27, 0.15) 0.59 0.91
rs3788050 7.3 Dominant 0.11 (0.00, 0.22) 0.04 (−0.39, 0.48) 0.12 (−0.10, 0.34) 0.27 0.85
Recessive −0.54 (−1.03, −0.05) −1.75 (−2.81, −0.68) 0.69 (0.19, 1.18) 0.007 0.45
rs234709 17.7 Dominant 0.06 (−0.06, 0.18) −0.36 (−0.68, −0.04) 0.23 (0.05, 0.41) 0.01 0.47
Recessive 0.13 (0.02, 0.24) −0.70 (−1.72, 0.33) 0.32 (−0.69, 1.33) 0.53 0.90
rs2124459 18.3 Dominant 0.06 (−0.07, 0.18) −0.33 (−0.67, 0.00) 0.26 (0.07, 0.44) 0.01 0.45
Recessive 0.14 (0.03, 0.25) −0.54 (−1.65, 0.57) 0.17 (−0.88, 1.21) 0.76 0.95
rs2849727 17.3 Dominant 0.07 (−0.04, 0.19) −0.27 (−0.58, 0.04) 0.20 (0.02, 0.37) 0.03 0.53
Recessive 0.13 (0.02, 0.23) −0.90 (−1.91, 0.11) 0.53 (−0.47, 1.53) 0.30 0.86
rs9983620 21.4 Dominant 0.12 (−0.01, 0.25) 0.02 (−0.28, 0.32) 0.01 (−0.16, 0.17) 0.95 0.98
Recessive −0.24 (−0.61, 0.13) −0.49 (−1.24, 0.26) 0.39 (0.01, 0.76) 0.04 0.57
CYBA rs3794624 10.9 Dominant 0.13 (0.02, 0.24) −0.07 (−0.43, 0.28) 0.01 (−0.19, 0.21) 0.90 0.98
Recessive 0.13 (0.02, 0.23) −1.00 (−2.23, 0.23) 2.10 (1.01, 3.20) <0.001 0.05
rs13306296 10.1 Dominant 0.13 (0.02, 0.24) −0.12 (−0.49, 0.24) 0.03 (−0.21, 0.15) 0.74 0.94
Recessive 0.13 (0.03, 0.23) −0.26 (−1.55, 1.03) 1.02 (0.22, 1.81) 0.01 0.47
GSTM1 rs4147567 4.0 Dominant 0.10 (0.00, 0.21) −0.25 (−0.82, 0.32) 0.30 (0.01, 0.58) 0.04 0.57
GSTP1 rs749174 18.0 Dominant 0.07 (−0.04, 0.19) −0.28 (−0.59, 0.03) 0.20 (0.02, 0.38) 0.03 0.49
Recessive 0.14 (0.03, 0.24) −0.78 (−1.82, 0.25) 0.49 (−0.54, 1.52) 0.35 0.88
IL6 rs2069845 17.6 Dominant 0.07 (−0.05, 0.19) −0.09 (−0.40, 0.21) 0.18 (0.004, 0.35) 0.04 0.57
Recessive 0.13 (0.02, 0.23) 0.63 (−0.54, 1.80) −0.05 (−0.89, 0.78) 0.90 0.98
rs1524107 20.4 Dominant 0.04 (−0.08, 0.16) −0.36 (−0.66, −0.06) 0.26 (0.08, 0.43) 0.004 0.45
Recessive 0.13 (0.03, 0.24) 0.21 (−0.69, 1.11) −0.02 (−0.63, 0.58) 0.94 0.98
rs1554606 7.8 Dominant 0.17 (0.07, 0.28) −0.13 (−0.55, 0.29) 0.29 (0.04, 0.54) 0.02 0.49
Recessive 0.14 (0.04, 0.24) 0.25 (−1.39, 1.90) −0.32 (−1.40, 0.76) 0.56 0.90
MTHFR rs9651118 16.9 Dominant 0.14 (0.02, 0.26) 0.03 (−0.28, 0.34) −0.04 (−0.21, 0.14) 0.69 0.93
Recessive 0.11 (0.01, 0.22) −0.54 (−1.34, 0.25) 0.48 (0.03, 0.94) 0.04 0.55
NOS3 rs743506 17.3 Dominant 0.15 (0.03, 0.26) 0.02 (−0.29, 0.32) −0.03 (−0.20, 0.14) 0.72 0.94
Recessive 0.12 (0.01, 0.22) −0.44 (−1.20, 0.32) 0.49 (0.04, 0.94) 0.03 0.53
rs1808593 12.2 Dominant 0.08 (−0.04, 0.19) 0.00 (−0.34, 0.34) 0.22 (0.03, 0.40) 0.02 0.49
PNP rs17882836 49.2 Dominant 0.06 (−0.11, 0.22) −0.21 (−0.56, 0.13) 0.10 (−0.09, 0.29) 0.30 0.86
Recessive −0.09 (−0.28, 0.10) −0.35 (−0.70, −0.01) 0.28 (0.08, 0.48) 0.01 0.45
rs1617940 17.3 Dominant 0.15 (0.03, 0.27) 0.03 (−0.28, 0.34) −0.05 (−0.22, 0.12) 0.58 0.90
Recessive 0.12 (0.02, 0.22) −0.45 (−1.23, 0.34) 0.47 (0.01, 0.92) 0.04 0.57
SOD2 rs10370 29.9 Dominant 0.11 (−0.03, 0.25) 0.10 (−0.20, 0.40) 0.04 (−0.13, 0.22) 0.61 0.91
Recessive 0.10 (−0.01, 0.21) −0.32 (−0.83, 0.20) 0.32 (0.06, 0.58) 0.02 0.47
rs12526686 43.7 Dominant 0.27 (0.11, 0.42) −0.30 (−0.60, 0.01) 0.23 (0.05, 0.40) 0.01 0.46
Recessive 0.14 (0.03, 0.25) −0.03 (−0.38, 0.33) −0.16 (−0.38, 0.07) 0.17 0.78
TNF rs1800630 39.6 Dominant 0.33 (0.17, 0.49) −0.42 (−0.10, −0.73) 0.26 (0.08, 0.43) 0.01 0.45
Recessive 0.17 (0.06, 0.28) −0.09 (−0.51, 0.34) −0.08 (−0.34, 0.17) 0.52 0.90
rs3179060 12.7 Dominant 0.08 (−0.04, 0.19) 0.01 (−0.32, 0.34) 0.20 (0.02, 0.38) 0.03 0.53
VCAM1 rs3176877 45.8 Dominant 0.28 (0.12, 0.44) −0.34 (−0.03, −0.66) 0.22 (0.04, 0.39) 0.02 0.47
Recessive 0.15 (0.04, 0.26) −0.03 (−0.38, 0.32) −0.13 (−0.34, 0.09) 0.26 0.85
rs3783617 17.1 Dominant 0.14 (0.03, 0.26) 0.02 (−0.30, 0.33) −0.02 (−0.20, 0.15) 0.78 0.95
Recessive 0.12 (0.02, 0.22) −0.54 (−1.34, 0.26) 0.48 (0.03, 0.94) 0.04 0.55
rs3917016 18.7 Dominant 0.20 (0.06, 0.33) −0.26 (−0.63, 0.10) 0.24 (0.03, 0.46) 0.02 0.49
Recessive 0.12 (0.00, 0.24) −0.32 (−1.24, 0.59) −0.20 (−0.95, 0.56) 0.60 0.91

Abbreviations: SNPs, single nucleotide polymorphisms; CI, confidence interval; PP, pulse pressure.

a

Recessive models are not shown for variants where fewer than 10 individuals possessed the homozygous recessive genotype

b

Coefficient in relation to interaction between well arsenic level and time

c

Coefficient in relation to interaction between each SNP in the dominant or recessive genetic models and time.

d

Coefficient in relation to the three-way interaction between each SNP, time and well arsenic in the dominant, or recessive genetic models.

e

P values for interaction adjusted for sex, age at enrollment, body mass index, smoking status (never, past, and current), educational attainment and diabetes at baseline, prior to FDR correction for multiple comparisons.

f

Q values are adjusted P values for interaction adjusted for sex, age at enrollment, body mass index, smoking status (never, past, and current), educational attainment and diabetes at baseline, after FDR correction for multiple comparisons.