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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Eur Neuropsychopharmacol. 2012 Oct 7;23(8):919–930. doi: 10.1016/j.euroneuro.2012.09.006

Figure 4. 5-HT induced changes in outcome related activity.

Figure 4

The figure illustrates changes in regional BOLD response to aversive and positive outcomes depending on the risk choice and the type of serotonergic challenge. Choices with odds of 1/7 and 2/7 were pooled together as high-risk, choices with odds of 3/7 and 4/7 as medium-risk and choices with odds of 5/7 and 6/7 as low-risk choices. (A) For unsuccessful low-risk choices, ATD increased and citalopram decreased dmPFC activity compared to the control condition. (B) Serotonergic challenges have no significant influence on dmPFC during positive outcomes. (C) For unsuccessful low-risk choices amygdala’s response decreased with ATD and increased with citalopram. (D) For high-risk positive outcomes amygdala’s response showed a bilateral decrease with ATD and increase with citalopram. The maps are thresholded at p<0.01 (uncorrected) for illustrative purposes. The right panels give the parameter estimates of the regional peaks for the low, medium and high-risk choices and the three pharmacological challenges. Error bars represent 90% confidence interval of the mean.