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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: J Psychopharmacol. 2013 Jul 2;27(10):903–914. doi: 10.1177/0269881113494106

Figure 5.

Figure 5

The figure summarizes the results of the PPI connectivity analysis exploring ketanserin related changes in OFC-amygdala connectivity during fear events (for details see methods section). (A) Maps showing the changes in coupling between the OFC seed region and the amygdala following acute 5-HT2A blockade. (B) Positive correlation between the OFC-amygdala connectivity and the interaction between neocortical 5-HT2A receptor binding (BPp) and ketanserin-induced 5-HT2A receptor occupancy (OKET10). The higher the OKET and the higher the neocortical BPP, the stronger was the individual increase in connectivity between the OFC and left amygdala. Values are mean normalized. The extent threshold of the SPMs is set at p<0.01 (uncorrected).