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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Leukemia. 2015 Jul 3;30(1):163–172. doi: 10.1038/leu.2015.174

Figure 5. Abnormal IL-10 production by B cells from BAFF receptor deficient mice.

Figure 5

(A) Serum IL-10 levels for C57BL/6, BAFF-Tg, BAFF−/−, TACI−/−, BAFF-R−/− and BCMA−/− mice at 12-mo of age were measured by ELISA (n=12 per group). (B) CD5+CD19+ splenic B cells isolated from of 12-mo old C57BL/6, BAFF-Tg, BAFF−/−, TACI−/−, BAFF-R−/− and BCMA−/− mice were assessed for intracellular IL-10 levels by flow cytometry. (C) CD5+CD19+ splenic B cells isolated from C57BL/6 and TACI−/− mice (n=6 per group) were cultured 12-h with or without LPS or CpG, and supernatants assessed for IL-10 levels by ELISA. In A-C, horizontal bars indicate the mean. In A-C, data are representative of at least three independent experiments.