Table 1.
Baseline characteristics, laboratory measurements, and distribution of SLC40A1 744 (G > T) polymorphism in the study participants
| Mild malaria | Malaria with hyperbilirubinaemia | Severe malaria | P-value | |
|---|---|---|---|---|
| (n = 72) | (n = 14) | (n = 17) | ||
| Male, n (%) | 56 (77.78) | 10 (71.43) | 9 (52.94) | 0.0592** |
| Age (year), median (IQR) | 36.00 (27.00–45.50) | 26.00 (20.25–36.25) | 37.00 (10.50–44.50) | 0.1274*** |
| Parasitaemia (parasites/μL), median (IQR) | 2673 (842–9313) | 2,451 (247–11,655) | 291 (0–29,184) | 0.2115*** |
| Laboratory measurements, median (IQR) | ||||
| Haemoglobin (g/dL) | 13.20 (12.50–14.28) | 11.75 (10.38–13.88) | 7.10 (6.50–10.50) | <0.0001*** |
| Haematocrit (%) | 43.50 (40.65–46.18) | 34.10 (30.20–41.45) | 23.10 (19.75–31.90) | <0.0001*** |
| Platelets (per mm3) | 108,500 (71,250–132,250) | 33,000 (18,000–51,250) | 64,000 (33,500–202,000) | 0.0003*** |
| AST (IU/L) | 67.50 (50.00–93.25) | 65.00 (36.00–172.50) | 34.00 (21.50–112.30) | 0.0686*** |
| ALT (IU/L) | 34.00 (19.25–50.75) | 104.50 (36.00–262.50) | 41.50 (13.25–76.00) | 0.0039*** |
| SLC40A1 744 (G > T) n (%) | ||||
| GG | 71 (98.61) | 14 (100.00) | 16 (94.12) | 0.4108** |
| GT | 1 (1.39) | 0 (0.00) | 1 (5.88) | |
| TT | 0 (0.00) | 0 (0.00) | 0 (0.00) | |
| G allele | 141 (99.30) | 28 (100.00) | 33 (97.06) | 0.4199** |
| T allele | 1 (0.70) | 0 (0.00) | 1 (2.94) | |
ALT alanine aminotransferase, AST aspartate aminotransferase, IQR interquartile range
** Categorized variables were compared using the Chi square test
*** Ordinal variables were compared using the Mann–Whitney test for two groups or the Kruskal–Wallis test with Dunn’s multiple comparison for three or more groups