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. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792

Figure 3. Large-scale temporal gene expression profiling reveals potential NOTCH1 target genes responsible for cartilage fibrosis and degradation.

Figure 3

P2 costal chondrocyte cultures isolated from control and Col2a1Cre; tetO-NICD1f/+; Rosa-rtTAf/+ mutant pups were treated with 10µg/ml DOX for 6 or 48 hours. RNA was collected for RNA-seq experiments. Each group contained three biological repeats. Log2(Fold Change) (Log2FC) of some genes of interest are shown, including Notch pathway genes, typical chondrogenic and catabolic genes, fibrous collagens, as well as genes from inflammatory signaling, tyrosine kinase signaling, GPCR signaling, and NO signaling. “*” denotes statistical significance with P<0.05 after Benjamini-Hochberg correction for multiple-testing (Cufflinks version 2.0.2).