Figure 1. Islet HA accumulates in tandem with progressive autoimmune insulitis in DORmO mice.
Representative histologic staining of pancreatic tissue from BALB/c (control) and DORmO mice and average islet area positive over time for (A–G) insulin (INS), (H–N) CD3, and (O–U) HA. For G, N, and U, at least 25 islets were visualized per mouse, and staining and data are from n = 6–8 mice per condition. Original magnification, ×40. Data represent mean ± SEM; *P < 0.05 vs. control for each time point by unpaired t test.