Figure 3. HA deposits characterize sites of insulitis in DORmO and human T1D.

(A and B) HA staining in pancreatic tissue isolated from (A) a DORmO mouse and (B) a human cadaveric donor with T1D. Infiltrated islets are circled in red; unaffected islets are circled in black. (C and D) HA staining of representative BALB/c and DORmO islets, demonstrating interstitial (orange arrowhead) and peri-islet (blue arrowheads) patterns of HA distribution. HA associated with lymphocytic infiltrates (red arrows) was only seen in DORmO mice. (E and F) Costaining of HA and DAPI, demonstrating HA accumulation in association with insulitis. (G and H) HA deposits in human insulitis (red arrows) from two cadaveric donors with T1D. Original magnification, ×40.