Figure 8. C/EBPα and TRIB1 are in a regulatory feedback loop that is both transcriptional and posttranslational.

(A) Differential C/EBPα binding peaks in the downstream region of Trib1 in Trib1_fl/fl, Trib1_LSKO, AAV_Null, and AAV_mCebpa mice, as measured by C/EBPα ChIP-Seq. n = 2 for this experiment, while only one mouse/group is shown. (B) Hepatic TRIB1 expression in AAV_Null and AAV_mCebpa mice (n = 5) 2 weeks after injection. (C) Schematic of the TRIB1- C/EBPα regulatory feedback loop. Results in B were analyzed by Student’s t test (**P ≤ 0.01).