| Yang 2012 |
Total 112 (56/56) |
Total 103 (56/56) |
Prospective randomized single-blind controlled trial |
aCGH |
<35 years; a history of regular ovulation; etiology of infertility was tubal factor or male factor (or both); no prior IVF treatment; no prior miscarriage; normal intrauterine contour; both ovaries intact; basal serum FSH<10 IU/l, basal estradiol<60 pg/ml. |
Treatment incorporated donor gametes or frozen/thawed embryos. |
ICSI; SET for both groups; all cycles involved day 6 blastocyst transfer; all cycles were fresh cycles. |
Laser-assisted hatching for all 6–8 cleavage stage embryos on day 3; 3–5 herniated TE cells removed; biopsy on blastocysts on day 5. |
Clinical pregnancy rate (same as implantation rate for SET); on-going pregnancy rate (more than 20 weeks GA); missed abortion rate. |
Randomization by random number table; concealment of allocation not reported; single-blind; 2 centers; full paper; power calculation not reported; no intention to treat. |
| Schoolcraft 2012 |
Total 60 (30/30) |
Total 60 (30/30) |
IRB approved randomized control trial |
SNP micro-array |
>35 years |
Exclusion criteria not reported. |
ART method not reported; number of embryos transferred not reported; all cycles involved blastocyst transfer; frozen cycles for PGS group, fresh cycles for control group. |
Biopsy method not reported; removed TE cells for biopsy. |
Implantation rate; first trimester pregnancy lose rate. |
Randomization by computer; concealment of allocation not reported; blinding not reported; one centre; only abstract; power calculation not reported; intention to treat. |
| Forman 2013 |
Total 175 (89/86) |
Total 175 (89/86) |
Randomized open label noninferiority trial |
Real-time, polymerase chain reaction-based CCS. |
<42 years; at most one prior failed IVF cycle; normal endometrial cavity; normal ovarian reverse (AMH>1.2 ng/mL, day 3 FSH<12 IU/L); at least 2 expanded blastocysts suitable for transfer or cryopreservation by day 6 of embryo development. |
Severe male infertility; anovulatory polycystic ovarian syndrome; BMI>30 kg/m2. |
ICSI; SET for CCS group, 2 blastocysts for control group. Fresh cycles involved day6 blastocyst transfer; frozen frozen cycles involved blastocyst transfer 5 days after starting P. Both groups involved fresh and frozen cycles. |
Laser-assisted hatching for all cleaved embryos on day 3; number of TE cells removed not reported; biopsy on blastocysts on day 5. |
Ongoing pregnancy rate; clinical miscarriage rate; sustained implantation rate; multiple pregnancy rate |
Randomization by computer; concealment of allocation achieved by sequentially numbered, opaque, sealed envelopes; not blinded; 1 center; full paper; power calculation; intention to treat; block randomization used for fresh and frozen cycles. |
| Scott 2013 |
Total 155 (72/83) |
Total 155 (72/83) |
Prospective randomized controlled trial |
Rapid quantitative real-time polymerase chain reaction (qPCR)-based comprehensive chromosome screening |
21–42 years; no more than one prior failed IVF retrieval; normal endometrial cavity; basal FSH level<15IU/L; basal follicle cunt >8; available ejaculate sperm; willingness to limit transfer order to a maximum 2 embryos; 2 or more blastocysts by the afternoon of day 5. |
Less than 2 blastocysts by day 5. |
ICSI; maximum 2 embryos for each patients. CCS group involved blastocysts transfer on day 6; control group involved blastocysts on day 5; all cycles were fresh cycles. |
Laser-assisted hatching for all embryos on day 3; number of TE cells removed not reported; biopsy on blastocysts on day 5. |
Implantation rate; pregnancy rate; delivery rate. |
Randomization by computer; concealment of allocation not reported; blind not reported; 1 center; full paper; power calculation; intention to treat; block randomization used for different age groups. |
