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DKK1 elevated IOP in mouse eyes. One eye (randomly selected) of each mouse was injected with Ad5-CMV-NULL, Ad5-CMV-DKK1, or Ad5-CMV-sFRP1 vector on day zero. The Ad5-CMV-NULL as well as contralateral uninjected eyes were used as negative controls. Conscious mouse IOPs were measured, and the mean and SEM of each group were plotted over time. The IOP values of DKK1 and sFRP1 transduced eyes were elevated significantly on days 7 to 15. Data were analyzed by ANOVA. ***P < 0.001.
