TABLE 2.
Clinicopathologic Variables of Patients According to MYC and TERC Gene Copy Status Based on the UCCC Criteria and ROC Classification
| UCCC Criteria |
ROC Classification |
UCCC Criteria |
ROC Classification |
|||||
|---|---|---|---|---|---|---|---|---|
|
MYC FISH + (n = 41, 36.2%) |
MYC FISH − (n = 72, 63.8%) |
MYC≥2.83 (n = 60, 53.1%) |
MYC<2.83 (n = 53, 46.9%) |
TERC FISH + (n = 41, 36.2%) |
TERC FISH − (n = 72, 63.8%) |
TERC≥2.65 (n = 58, 51.3%) |
TERC<2.65 (n = 55, 48.7%) |
|
| Sex, n (%) | ||||||||
| Female | 6 (14.6) | 12 (16.7) | 9 (50.0) | 9 (50.0) | 4 (9.8) | 14 (19.4) | 7 (38.9) | 11 (66.1) |
| Male | 35 (85.4) | 60 (83.3) | 51 (53.6) | 44 (46.3) | 37 (90.2) | 58 (80.6) | 51 (53.7) | 44 (46.3) |
| P | 1.0 | 0.77 | 0.28 | 0.25 | ||||
| Smoking, n (%) | ||||||||
| Former/ current |
40 (97.6) | 64 (88.9) | 56 (53.8) | 48 (46.3) | 40 (97.6) | 64 (88.9) | 56 (53.8) | 48 (46.2) |
| Never | 1 (2.4) | 8 (11.1) | 4 (44.4) | 5 (55.6) | 1 (2.4) | 8 (11.1) | 2 (22.2) | 7 (77.8) |
| P | 0.15 | 0.58 | 0.15 | 0.06 | ||||
| pTNM stage, n (%) | ||||||||
| I | 25 (61.0) | 45 (62.5) | 39 (55.7) | 31 (44.2) | 24 (58.5) | 46 (63.9) | 36 (51.4) | 34 (48.6) |
| II | 9 (22.0) | 9 (12.5) | 10 (55.6) | 8 (44.8) | 7 (17.1) | 11 (15.3) | 10 (55.6) | 8 (44.4) |
| III | 7 (17.0) | 18 (25.0) | 11 (44.0) | 14 (56.0) | 10 (24.4) | 15 (20.8) | 12 (48.0) | 13 (52.0) |
| P | 0.32 | 0.58 | 0.81 | 0.88 | ||||
| Histology, n (%) | ||||||||
| Squamous | 23 (56.1) | 35 (48.1) | 32 (55.2) | 26 (44.8) | 31 (75.6) | 27 (37.5) | 42 (72.4) | 16 (27.6) |
| Non | 18 (43.9) | 37 (51.4) | 28 (50.9) | 27 (40.1) | 10 (24.4) | 45 (62.5) | 16 (29.1) | 39 (20.9) |
| Squamous | ||||||||
| P | 0.56 | 0.65 | 0.0001 | < 0.0001 | ||||
| Grading, n (%) | ||||||||
| Well | 2 (4.9) | 10 (13.9) | 6 (50.0) | 6 (50.0) | 3 (7.3) | 9 (12.5) | 6 (50.0) | 6 (50.0) |
| Moderately | 19 (46.3) | 32 (44.4) | 27 (53.0) | 24 (47.0) | 20 (48.8) | 31 (43.0) | 24 (47.1) | 27 (52.9) |
| Poorly | 20 (48.8) | 30 (41.7) | 27 (54.0) | 23 (46.0) | 18 (43.9) | 32 (44.5) | 25 (50.0) | 25 (50.0) |
| P | 0.34 | 0.56 | 0.72 | 0.95 | ||||
FISH indicates fluorescence in situ hybridization; ROC, receiver operating characteristic classification; UCCC, The University of Colorado Cancer Center criteria.