TABLE 4.

Multivariate Analyses of Disease-free Survival and Overall Survival for Variables Considered

	Multivariate Analysis
	Disease-free Survival			Overall Survival
Variables	HR	95% CI	P	HR	95% CI	P
Model 1
MYC FISH (positive/negative)*	1.92	1.09-3.38	0.02	1.01	1.07-2.97	0.02
TNM stage (II-III/I)	3.68	2.01-6.73	< 0.0001	2.68	1.56-4.61	< 0.0001
Age (y) continuous	1.0	0.97-1.04	0.64	1.01	0.98-1.05	0.26
Model 2
MYC GCN (≥2.83/<2.83 copies)†	1.97	0.97-3.54	0.02	2.05	1.20-3.50	0.008
TNM stage (II-III/I)	3.52	1.93-6.43	< 0.0001	2.88	1.66-4.98	< 0.0001
Age (y) continuous	1.01	0.97-1.04	0.49	1.02	0.98-1.05	0.18

^*Using the University of Colorado Cancer Center (UCCC) criteria the tumors were considered FISH-positive when ≥4 gene copies displayed in ≥40% of tumor cells

^†Receiver operating characteristic (ROC) classification.

CI indicates confidence interval; FISH, fluorescence in situ hybridization; GCN, gene copy number; HR, hazard ratio.