Table 3. Uni- and multivariate Cox regression analysis for risk of biochemical recurrence.
In addition to entire study cohort, a subpopulation of patients with GS>6 tumor was analyzed separately.
| Entire group | Subgroup (GS>6) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||||
| Variable | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Gleason score | |||||||||||||
| <7 | ref | ref | na | na | |||||||||
| 7 | 1.9 | 1.2–3.0 | <0.003* | 1.3 | 0.8–2.3 | 0.32 | ref | ref | |||||
| >7 | 4.8 | 3.0–7.5 | <0.001* | 2.6 | 1.5–4.7 | 0.001* | 2.4 | 1.7–3.5 | <0.001* | 2.0 | 1.0–3.3 | <0.002* | |
| sPSA | |||||||||||||
| Continuous | 1.06 | 1.05–1.08 | <0.001* | 1.04 | 1.02–1.06 | <0.001* | 1.05 | 1.04–1.07 | <0.001* | 1.04 | 1.02–1.06 | <0.001* | |
| pT category a | |||||||||||||
| pT2 | ref | ref | ref | ref | |||||||||
| pT3 | 3.1 | 2.1–4.6 | <0.001* | 2.2 | 1.3–3.5 | 0.002* | 2.3 | 1.4–3.7 | 0.001* | 1.7 | 1.0–2.9 | 0.053 | |
| Lamin A | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 1.0 | 0.7–1.3 | 0.85 | 0.81 | 0.5–1.2 | 0.29 | 0.9 | 0.6–1.3 | 0.58 | 0.7 | 0.5–1.1 | 0.15 | |
| Lamin B1 | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 1.5 | 1.0–2.2 | 0.04* | 1.8 | 1.1–2.9 | 0.023* | 1.7 | 1.0–2.7 | 0.036* | 1.6 | 0.9–2.9 | 0.077 | |
| Lamin B2 | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 1.1 | 0.8–1.6 | 0.48 | 0.95 | 0.6–1.4 | 0.81 | 0.95 | 0.6–1.4 | 0.82 | 0.85 | 0.5–1.4 | 0.49 | |
| Lamin C | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 1.0 | 0.5–1.9 | 0.88 | 0.70 | 0.3–1.7 | 0.41 | 1.1 | 0.5–2.5 | 0.9 | 0.58 | 0.2–1.7 | 0.32 | |
HR, hazard ratio (describes the relative risk of the event at any given time based on comparing the group with the reference group); 95% CI, 95% confidence interval (A 95% confidence interval means that 95% of the values of an unobservable parameter of interest would set in the interval if the experiment is repeated); na, not available; ref, reference
* Significant p-value
a Pathological T category refers to the stage of primary tumor in the TNM tumor staging system. pT2 = Tumor confined within prostate, pT3 = Tumor invading extraprostatic tissue and/or seminal vesicle(s).