Table 4. Uni- and multivariate Cox regression analysis for risk of prostate cancer-specific death.
In addition to entire study cohort, a subpopulation of patients with GS>6 tumor was analyzed separately.
| Entire group | Subgroup (GS>6) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||||
| Variable | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Gleason score | |||||||||||||
| <7 | ref | ref | na | na | |||||||||
| 7 | 8.8 | 1.0–71.0 | 0.042* | 9.3 | 1.1–77.4 | 0.039* | ref | ref | |||||
| >7 | 28.9 | 3.7–224.7 | 0.001* | 37.6 | 4.8–296.2 | 0.001* | 3.3 | 1.4–8.0 | 0.008* | 3.0 | 0.9–9.3 | 0.063 | |
| sPSA | |||||||||||||
| Continuous | 1.80 | 0.99–3.24 | 0.051 | 1.02 | 0.98–1.07 | 0.31 | |||||||
| pT category a | |||||||||||||
| T2 | ref | ref | |||||||||||
| T3 | 60.3 | 1.4–2688.4 | 0.034* | 41.4 | 0.6–2642.6 | 0.079 | |||||||
| N category b | |||||||||||||
| N0 | ref | ref | |||||||||||
| N1 | 6.5 | 2.5–16.9 | <0.001* | 5.5 | 2.1–14.6 | 0.001* | |||||||
| Lamin A | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 0.3 | 0.2–1.5 | 0.27 | 0.4 | 0.16–1.0 | 0.052 | 0.4 | 0.1–1.0 | 0.052 | 0.4 | 0.2–1.2 | 0.11 | |
| Lamin B1 | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 1.5 | 0.4–5.1 | 0.55 | 1.6 | 0.5–5.7 | 0.44 | 1.4 | 0.4–5.1 | 0.57 | 1.7 | 0.5–6.1 | 0.40 | |
| Lamin B2 | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 0.5 | 0.2–1.2 | 0.11 | 0.41 | 0.17–0.99 | 0.047* | 0.4 | 0.2–1.0 | 0.058 | 0.6 | 0.2–1.6 | 0.29 | |
| Lamin C | |||||||||||||
| Low | ref | ref | ref | ref | |||||||||
| High | 0.4 | 0.2–1.2 | 0.095 | 0.2 | 0.1–0.6 | 0.004* | 0.3 | 0.1–0.8 | 0.023* | 0.3 | 0.1–0.9 | 0.03* | |
HR, hazard ratio (describes the relative risk of the event at any given time based on comparing the group with the reference group); 95% CI, 95% confidence interval (A 95% confidence interval means that 95% of the values of an unobservable parameter of interest would set in the interval if the experiment is repeated); na, not available; ref, reference
* Significant p-value
a pathological tumor (pT) category refers to the stage (i.e. size and extent) of primary tumor in the TNM tumor staging system. pT2 = Tumor confined within prostate, pT3 = Tumor invading extraprostatic tissue and/or seminal vesicle(s).
b N category describes in TNM system weather (N1) or not (N0) the cancer has spread to the regional lymph nodes.