Table 2. Risk of subsequent primary cancers by latency, age, and year of diagnosis following cancer of the prostate diagnosed between 1993 and 2011.
| Total | Latency (months) | Age (years) | Year of diagnosis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| <60 | 60–119 | ≥120 | < 65 years | ≥ 65 years | 1993–2000 | 2001–2011 | |||
| SIR (O/E) | 95% CI | SIR (O/E) | SIR (O/E) | SIR (O/E) | SIR (O/E) | SIR (O/E) | SIR (O/E) | SIR (O/E) | |
| All subsequent cancers | 0.68# (2761/4067.46) | (0.65, 0.70) | 0.68# (2115/3100.39) | 0.67# (544/806.21) | 0.63# (102/160.86) | 0.78# (598/766.62) | 0.66# (2163/3300.84) | 0.60# (496/831.08) | 0.70# (2265/3236.38) |
| All subsequent cancers (excluding prostate) | 0.75# (2738/3649.18) | (0.72, 0.78) | 0.75# (2094/2788.74) | 0.75# (542/718.27) | 0.72# (102/142.17) | 0.84# (591/706.05) | 0.73# (2147/2943.13) | 0.64# (492/763.54) | 0.78# (2246/2885.64) |
| Buccal cavity, pharynx | 0.81 (54/66.39) | (0.61, 1.06) | 0.81 (42/51.54) | 0.56 (7/12.51) | 2.14 (5/2.33) | 0.79 (12/15.22) | 0.82 (42/51.16) | 0.85 (12/14.11) | 0.80 (42/52.28) |
| Digestive system | 0.72# (1523/2122.91) | (0.68, 0.75) | 0.71# (1163/1629.53) | 0.74# (306/412.93) | 0.67# (54/80.46) | 0.73# (320/441.06) | 0.72# (1203/1681.85) | 0.62# (273/437.28) | 0.74# (1250/1685.63) |
| Esophagus | 0.62# (65/104.95) | (0.48, 0.79) | 0.69# (56/81.35) | 0.45# (9/19.94) | 0.00 (0/3.65) | 0.58 (12/20.85) | 0.63# (53/84.1) | 0.46# (11/24.11) | 0.67# (54/80.84) |
| Stomach | 0.69# (549/797.53) | (0.63, 0.75) | 0.67# (413/615.13) | 0.78# (119/153.3) | 0.58# (17/29.1) | 0.79# (132/166.21) | 0.66# (417/631.32) | 0.64# (110/172.99) | 0.70# (439/624.54) |
| Small intestine | 0.91 (12/13.21) | (0.47, 1.59) | 0.79 (8/10.08) | 1.15 (3/2.61) | 1.95 (1/0.51) | 0.41 (1/2.46) | 1.02 (11/10.75) | 0.70 (2/2.84) | 0.96 (10/10.37) |
| Colon | 1.00 (315/315.71) | (0.89, 1.11) | 1.05 (252/239.55) | 0.81 (51/63.24) | 0.93 (12/12.92) | 0.96 (61/63.35) | 1.01 (254/252.36) | 0.74 (39/52.87) | 1.05 (276/262.84) |
| Rectum, rectosigmoid | 0.66# (164/249.18) | (0.56, 0.77) | 0.65# (125/191) | 0.66# (32/48.67) | 0.74 (7/9.52) | 0.70# (38/54.41) | 0.65# (126/194.78) | 0.57# (26/45.6) | 0.68# (138/203.59) |
| Anus, anal canal | 0.60 (3/5.01) | (0.12, 1.75) | 0.27 (1/3.77) | 1.95 (2/1.03) | 0.00 (0/0.22) | 1.34 (1/0.75) | 0.47 (2/4.27) | 0.77 (1/1.3) | 0.54 (2/3.72) |
| Liver | 0.56# (155/276.09) | (0.48, 0.66) | 0.52# (113/216.46) | 0.67# (34/50.47) | 0.87 (8/9.16) | 0.43# (32/74.67) | 0.61# (123/201.42) | 0.59# (35/59.61) | 0.55# (120/216.48) |
| Gall bladder | 0.60# (31/52.03) | (0.40, 0.85) | 0.59# (23/39.05) | 0.75 (8/10.71) | 0.00 (0/2.27) | 0.64 (5/7.83) | 0.59# (26/44.2) | 0.35# (4/11.5) | 0.67# (27/40.53) |
| Bile ducts, other biliary | 0.77# (141/184.13) | (0.64, 0.90) | 0.74# (102/138.6) | 0.88 (33/37.64) | 0.76 (6/7.89) | 0.79 (23/29.09) | 0.76# (118/155.04) | 0.77 (31/40.1) | 0.76# (110/144.03) |
| Pancreas | 0.72# (87/120.67) | (0.58, 0.89) | 0.76# (69/91.12) | 0.61 (15/24.47) | 0.59 (3/5.07) | 0.73 (15/20.56) | 0.72# (72/100.1) | 0.55# (14/25.28) | 0.77# (73/95.39) |
| Respiratory system | 0.64# (559/872.74) | (0.59, 0.70) | 0.62# (410/662.58) | 0.73# (128/175.13) | 0.60# (21/35.03) | 0.75# (105/139.35) | 0.62# (454/733.4) | 0.51# (99/192.69) | 0.68# (460/680.06) |
| Nose, nasal cavity, ear | 0.28 (2/7.05) | (0.03, 1.02) | 0.37 (2/5.45) | 0.00 (0/1.34) | 0.00 (0/0.26) | 0.68 (1/1.46) | 0.18# (1/5.59) | 0.00 (0/1.56) | 0.36 (2/5.49) |
| Larynx | 0.68# (35/51.17) | (0.48, 0.95) | 0.55# (22/39.84) | 1.35 (13/9.6) | 0.00 (0/1.73) | 0.55 (6/10.86) | 0.72 (29/40.31) | 0.65 (8/12.23) | 0.69 (27/38.94) |
| Lung, bronchus | 0.64# (521/810.9) | (0.59, 0.70) | 0.63# (386/614.51) | 0.70# (114/163.48) | 0.64# (21/32.9) | 0.77# (97/126.43) | 0.62# (424/684.47) | 0.51# (90/177.89) | 0.68# (431/633.01) |
| Male genital system | 0.08# (32/425.39) | (0.05, 0.11) | 0.09# (27/317.05) | 0.04# (4/89.37) | 0.05# (1/18.98) | 0.13# (8/61.73) | 0.07# (24/363.67) | 0.09# (6/69.3) | 0.07# (26/356.1) |
| Prostate | 0.05# (23/418.28) | (0.03, 0.08) | 0.07# (21/311.65) | 0.02# (2/87.94) | 0.00# (0/18.69) | 0.12# (7/60.57) | 0.04# (16/357.71) | 0.06# (4/67.54) | 0.05# (19/350.74) |
| Testis | 3.49 (2/0.57) | (0.42, 12.61) | 4.45 (2/0.45) | 0.00 (0/0.11) | 0.00 (0/0.02) | 6.52 (1/0.15) | 2.39 (1/0.42) | 0.00 (0/0.15) | 4.76 (2/0.42) |
| Male Breast | 0.37 (1/2.68) | (0.01, 2.08) | 0.49 (1/2.02) | 0.00 (0/0.54) | 0.00 (0/0.12) | 0.00 (0/0.44) | 0.45 (1/2.24) | 0.00 (0/0.66) | 0.50 (1/2.02) |
| Urinary system | 1.24# (304/246.13) | (1.10, 1.38) | 1.31# (244/185.98) | 1.04 (52/49.82) | 0.77 (8/10.33) | 1.69# (71/41.98) | 1.14 (233/204.15) | 1.16 (60/51.61) | 1.25# (244/194.52) |
| Urinary bladder | 1.26# (197/156.56) | (1.09, 1.45) | 1.32# (155/117.32) | 1.11 (36/32.35) | 0.87 (6/6.88) | 2.03# (45/22.17) | 1.13 (152/134.39) | 1.39# (50/35.92) | 1.22# (147/120.63) |
| Kidney parenchyma | 1.15 (74/64.63) | (0.90, 1.44) | 1.26 (63/49.82) | 0.73 (9/12.39) | 0.83 (2/2.41) | 1.22 (19/15.53) | 1.12 (55/49.09) | 0.46 (5/10.96) | 1.29# (69/53.66) |
| Renal pelvis, other urinary | 1.32 (33/24.95) | (0.91, 1.86) | 1.38 (26/18.83) | 1.38 (7/5.07) | 0.00 (0/1.04) | 1.64 (7/4.28) | 1.26 (26/20.67) | 1.06 (5/4.73) | 1.38 (28/20.22) |
| Ureter | 1.30 (16/12.34) | (0.74, 2.11) | 1.41 (13/9.24) | 1.17 (3/2.56) | 0.00 (0/0.54) | 2.01 (4/1.99) | 1.16 (12/10.35) | 0.44 (1/2.26) | 1.49 (15/10.09) |
| Soft tissue including heart | 1.08 (13/12) | (0.58, 1.85) | 0.99 (9/9.07) | 1.24 (3/2.41) | 1.92 (1/0.52) | 1.29 (3/2.32) | 1.03 (10/9.68) | 0.42 (1/2.4) | 1.25 (12/9.61) |
| Melanoma of the skin | 1.14 (9/7.87) | (0.52, 2.17) | 1.18 (7/5.95) | 1.26 (2/1.59) | 0.00 (0/0.33) | 0.00 (0/1.44) | 1.40 (9/6.44) | 0.68 (1/1.47) | 1.25 (8/6.4) |
| Brain, CNS | 0.77 (14/18.21) | (0.42, 1.29) | 0.72 (10/13.95) | 0.85 (3/3.55) | 1.41 (1/0.71) | 2.04 (8/3.91) | 0.42# (6/14.3) | 0.84 (3/3.59) | 0.75 (11/14.62) |
| Thyroid | 2.06# (80/38.87) | (1.63, 2.56) | 2.22# (69/31.05) | 1.34 (9/6.71) | 1.80 (2/1.11) | 2.38# (37/15.53) | 1.84# (43/23.34) | 2.10 (9/4.28) | 2.05# (71/34.59) |
| Lymphatic, hematopoietic | 0.85 (103/121.2) | (0.69, 1.03) | 0.86 (80/92.52) | 0.84 (20/23.91) | 0.63 (3/4.77) | 0.99 (24/24.36) | 0.82 (79/96.83) | 0.90 (21/23.24) | 0.84 (82/97.96) |
# P <0.05
SIR, standardized incidence ratio; O, observed number of second primary cancers; E, expected number of second primary cancers; O/E, ratio of observed number of second primary cancers to the number of expected cancers; 95% CI, 95% confidence interval; CNS, central nervous system