Table 3. Univariate and multivariate Cox proportional hazards models predicting overall survival and cancer-specific survival in 472 patients with UTUC.

Age	Overall survival						Cancer-specific Survival
	Univariate			Multivariate			Univariate			Multivariate
Variables	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Age
> 67 vs. ≦ 67	1.519	1.083–2.131	0.015	1.598	1.109–2.304	0.012	1.595	1.109–2.295	0.012	1.647	1.111–2.442	0.013
Gender
Male vs. Female	1.343	0.963–1.874	0.082	1.238	0.820–1.868	0.310	1.216	0.850–1.737	0.284	1.125	0.722–1.753	0.603
Smoking
Yes vs. No	1.201	0.809–1.784	0.363	1.295	0.786–2.134	0.309	1.102	0.714–1.701	0.662	1.321	0.763–2.289	0.320
Preoperative eGFR (ml/min/1.73m 2 )
< 60 vs. ≧ 60	1.485	1.017–2.169	0.041	1.577	1.045–2.382	0.030	1.699	1.117–2.586	0.013	1.691	1.071–2.669	0.024
Surgery method
Laparoscopic vs. Open	0.797	0.557–1.139	0.213	0.955	0.652–1.399	0.813	0.784	0.535–1.150	0.214	0.949	0.630–1.429	0.803
Tumor location			0.032			0.236			0.082			0.268
Ureter vs. Renal pelvis	1.183	0.803–1.742	0.396	0.912	0.601–1.384	0.664	1.002	0.664–1.512	0.993	0.803	0.515–1.252	0.333
Synchronous vs. Renal pelvis	1.785	1.149–2.775	0.010	1.336	0.844–2.117	0.217	1.605	1.007–2.556	0.047	1.199	0.737–1.951	0.465
Pathological tumor stage			<0.001			<0.001			<0.001			<0.001
T1 vs. Tis/a	1.057	0.465–2.401	0.895	1.061	0.459–2.453	0.890	1.624	0.606–4.352	0.335	1.529	0.561–4.168	0.407
T2 vs. Tis/a	1.924	0.882–4.197	0.100	2.066	0.880–4.850	0.096	2.269	0.859–5.993	0.098	2.171	0.766–6.154	0.145
T3 vs. Tis/a	4.162	1.991–8.700	<0.001	3.407	1.458–7.964	0.005	5.988	2.396–14.964	<0.001	4.438	1.606–12.266	0.004
T4 vs. Tis/a	17.146	7.494–39.229	<0.001	5.767	2.061–16.139	0.001	27.043	10.079–72.558	<0.001	8.530	2.634–27.624	<0.001
Pathological lymph nodal status			<0.001			0.002			<0.001			0.005
pNx vs. pN0	1.276	0.858–1.899	0.229	1.160	0.775–1.735	0.471	1.274	0.829–1.957	0.269	1.179	0.763–1.823	0.458
pN1/2 vs. pN0	8.334	5.036–13.792	<0.001	3.109	1.657–5.835	<0.001	8.791	5.168–14.956	<0.001	2.943	1.522–5.691	0.001
Tumor grade
High vs. Low	2.404	1.507–3.835	<0.001	0.959	0.537–1.715	0.888	2.983	1.733–5.137	<0.001	1.202	0.621–2.328	0.586
Adjuvant chemotherapy
Yes vs. No	2.914	2.048–4.148	<0.001	1.350	0.884–2.062	0.165	3.009	2.066–4.381	<0.001	1.313	0.837–2.058	0.236
Hematuria
Yes vs. No	0.495	0.317–0.771	0.002	0.616	0.378–1.003	0.051	0.477	0.312–0.729	0.001	0.640	0.380–1.077	0.093
HN and flank pain			<0.001			0.078			0.001			0.130
Flank pain without HN vs. no HN and flank pain	1.121	0.521–2.413	0.770	1.561	0.696–3.499	0.280	1.264	0.582–2.743	0.554	1.780	0.783–4.049	0.169
HN without flank pain vs. no HN and flank pain	1.301	0.848–1.996	0.228	1.146	0.730–1.799	0.553	1.254	0.795–1.978	0.329	1.140	0.705–1.842	0.594
HN with flank pain vs. no HN and flank pain	2.835	1.804–4.454	<0.001	1.975	1.137–3.433	0.016	2.607	1.603–4.238	<0.001	1.874	1.042–3.371	0.036

eGFR estimated glomerular filtration, HN hydronephrosis.