Fig 1. Increased inhibitory synaptic transmission at LII/III synapses from Nlgn3^R451C mice.

mIPSC frequency (A), but not amplitude (B) of spontaneous inhibitory transmission in the presence of 1 μM TTX is increased Nlgn3^R451C mice (WT = 39, Nlgn3^R451C = 32). Inset: 15s raw trace from a WT (top) and Nlgn3^R451C (bottom) mouse. Scale bar: 25 pA; 0.5 s. C) The input/output (I/O) relationship of eIPSC amplitude to stimulus intensity is stronger in Nlgn3^R451C mice compared to WT controls (WT = 33, Nlgn3^R451C = 30). * P < 0.05, ** P < 0.01.