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. 2015 Oct 15;10(10):e0140638. doi: 10.1371/journal.pone.0140638

Fig 3. Bidirectional unitary postsynaptic responses at PV → PYR synapses are normal in Nlgn3R451C mice.

Fig 3

A) Simplified schematic of a PV → PYR synapse. B) Representative traces averaged from 20 consecutive sweeps (including failures). A short 20 Hz train of 5 action potentials is elicited from the presynaptic PV interneuron (in voltage clamp, top) and unitary IPSC (uIPSCs) are recorded from the postsynaptic pyramidal neuron (WT = middle; Nlgn3R451C = bottom). Scale bars: 500 pA (PV), 25 pA (PYR); 25 ms. C) Scatter plot of uIPSC1 amplitude for each connected pair from WT (n = 34) and Nlgn3R451C (n = 29). D) Scatter plot of uEPSC1 of connected PYR → PV pairs showing no difference in excitatory transmission onto PV interneurons between WT (n = 19) and Nlgn3R451C (n = 12).