Table 1. Summary of intrinsic membrane properties of neurons from WT and Nlgn3R51C mice.
The resting membrane potential (RMP), capacitance (Cm), input resistance (RInput), and firing threshold of each cell was measured immediately following break-in. Data are represented as mean ± SEM.
| Property | Cell Type | WT | Nlgn3R451C | Student’s t-test | Significance |
|---|---|---|---|---|---|
| RMP (mV) | PV | -61.69 ± 1.48, n = 33 | -59.01 ± 3.16, n = 38 | t (69) = 0.73 | P = 0.467 |
| SOM | -54.94 ± 1.76, n = 31 | -62.09 ± 1.84, n = 29 | t (58) = 2.81 | P = 0.007 | |
| PYR | -65.78 ± 1.74, n = 53 | -64.01 ± 2.14, n = 52 | t (103) = 0.64 | P = 0.521 | |
| Cm (pF) | PV | 45.70 ± 4.06, n = 33 | 59.61 ± 4.65, n = 38 | t (69) = 2.22 | P = 0.030 |
| SOM | 67.30 ± 4.95, n = 31 | 74.93 ± 5.22, n = 29 | t (58) = 1.06 | P = 0.293 | |
| PYR | 75.14 ± 3.19, n = 52 | 73.73 ± 3.79, n = 52 | t (102) = 0.28 | P = 0.777 | |
| RInput (MΩ) | PV | 194.1 ± 23.32, n = 33 | 170.1 ± 26.13, n = 38 | t (69) = 0.68 | P = 0.501 |
| SOM | 328.9 ± 26.54, n = 31 | 360.2 ± 46.06, n = 29 | t (58) = 0.60 | P = 0.552 | |
| PYR | 261.3 ± 17.18, n = 52 | 236.3 ± 16.08, n = 52 | t (102) = 1.06 | P = 0.290 | |
| Threshold (pA) | PV | 142.4 ± 21.33, n = 33 | 117.1 ± 12.30, n = 38 | t (69) = 1.06 | P = 0.292 |
| SOM | 32.26 ± 5.34, n = 31 | 44.83 ± 5.46, n = 29 | t (58) = 1.65 | P = 0.105 | |
| PYR | 71.35 ± 7.02, n = 48 | 71.00 ± 4.97, n = 50 | t (96) = 0.04 | P = 0.967 |