Table 1. Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.
| Parameter | Pre-Effective Stimulation mean ± SD | Post-Effective Stimulation mean ± SD | Effective Stimulation P-value | Pre-Sham Stimulation mean ± SD | Post-Sham Stimulation mean ± SD | Sham Stimulation P-value |
|---|---|---|---|---|---|---|
| Age (years) | 62.27 ± 7.94 (range, 49–75) | |||||
| Gender (M/F) | 5/6 | |||||
| DD (years) | 7.50 ± 2.22 (range, 4–10) | |||||
| H&Y stage | 2.32 ± 0.25 (range, 2.00–2.50) | |||||
| MMSE | 29.55 ± 0.82 (range, 28–30) | |||||
| Side (R/L) | 7/4 | |||||
| LEDD (mg/day) | 789 ± 123 (range, 580–1000) | |||||
| UPDRS III OFF medication | 30.55 ± 6.95 # 32.14 ± 7.58* | 19.27 ± 6.36 # 21.14 ± 7.10* | <0.001 # 0.016 * | 27.27 ± 8.04 # 28.71 ± 9.69* | 27.82 ± 7.21 # 29.57 ± 8.06* | 0.868 # 0.860* |
| Tremor subscore a | 2.91 ± 3.50 # 2.92 ± 4.11* | 2.18 ± 2.44 # 1.57 ± 2.57* | 0.578 # 0.704* | 3.45 ± 3.27 # 3.14 ± 3.80* | 3.73 ± 3.29 # 3.29 ± 3.82* | 0.847 # 0.945* |
| PIGD subscore b | 6.18 ± 3.49 # 7.43 ± 3.46* | 3.09 ± 2.38 # 4.00 ± 2.45* | 0.025 # 0.053 * | 4.55 ± 2.02 # 5.14 ± 1.95* | 5.09 ± 2.38 # 5.71 ± 2.21* | 0.569 # 0.618* |
| PIGD sub score with no freezing | 5.36 ± 2.87 # 6.43 ± 2.88* | 2.64 ± 2.06 # 3.43 ± 2.15* | 0.019 # 0.047 * | 3.91 ± 1.76 # 4.43 ± 1.72* | 4.27 ± 1.95 # 4.86 ± 1.95* | 0.651 # 0.670* |
| Rigidity subscore c | 6.36 ± 2.58 # 6.71 ± 3.09* | 4.64 ± 2.87 # 5.43 ± 3.41* | 0.153 # 0.474* | 5.64 ± 2.20 # 5.86 ± 2.54* | 5.45 ± 2.34 # 5.57 ± 2.37* | 0.853 # 0.831* |
Acronyms: M: male; F: female; DD: disease duration; H&Y: Hoehn and Yahr; MMSE: Mini-Mental State Examination; Side: Symtom-dominant side; LEDD: L-dopa equivalent daily dose; UPDRS: Unified Parkinson’s Disease Rating Scale; PIGD: Postural Instability Gait Disturbances
# Data from the total group of patients (n = 11)
* Data from the group of patients eligible for fMRI analysis (n = 7).
a Tremor sub score represents the sum of the UPDRS items in OFF condition: 3.15, 3.16, 3.17 e 3.18.
b PIGD subscore represents the sum of the UPDRS items in OFF condition: 3.9, 3.10, 3.11, 3.12, 3.13, 3.14.
c Rigidity subscore represents the sum of the UPDRS items in OFF condition: 3.3.
Statistically significant P-values (p < 0.05) are presented in bold.