. 2015 Oct 15;11(10):e1004314. doi: 10.1371/journal.pcbi.1004314

Table 2. Shared parameter values.

No.	Symbol	Description	Fixed/Fitted	Mean	Std. Dev.	Units
1	k _PG	Pathogen growth	Fixed	1	0	Hour^-1
2	$k_{P G - N_{K / M}}$	Neutrophil induced pathogen death	Fitted	145.5391	0.040553	(Hour *10³ cells/μl)^-1
3	k _PL	Pathogen population limit	Fitted	1.6533E-7	2.3409E-7	(Hour*CFU)^-2
4	k _P	Pathogen decay	Fitted	271.9904	352.4858	CFU/Hour
5	$k_{p}^{d}$	Pathogen decay	Fixed	1000	0	CFU
6	$k_{N_{B}}$	Basal neutrophil natural	Fixed	0.1	0	Hour^-1
7	*$k_{N_{K}}$*	Killer neutrophil decay	Fitted	0.0330	0.0275	Hour^-1
8	$k_{N_{M}}$	Migratory neutrophil decay	Fitted	0.1244	0.1936	Hour^-1
9	$k_{N_{K / M}}$	Migratory-Killer neutrophil decay	Fitted	0.1176	0.1772	Hour^-1
10	$k_{N_{M} - N_{K} - I L 8}$	IL-8 induced migratory neutrophil to neutrophil migratory-killer transition	Fitted	168.7708	260.7247	Hour^-1
11	k _IL8−P	Pathogen induced IL-8 production	Fitted	2.7810E-6	2.0441E-6	Hour^-1
12	k _IL8−D	Tissue damage induced IL-8 production	Fitted	5.7938E-9	7.9615E-9	nM*Hour^-1
13	k _IL8	IL-8 decay	Fitted	0.3352	0.0261	Hour^-1
14	$k_{D - N_{K}}$	Tissue damage induced by killer neutrophils	Fitted	0.0319	0.0285	(Hour *10³ cells/μl)^-1
15	k _D	Damage recovery rate	Fitted	7.0147	8.8870	Hour^-1
16	k _{filter_on}	Filter production rate	Fitted	6.1698E-4	8.2047E-4	(CFU*Hour)^-1
17	k _r1	Dissociation constant for R1 receptors	Fixed	79.2	0	Hour^-1
18	k _r2	Dissociation constant for R2 receptors	Fixed	79.2	0	Hour^-1
19	k _D	Affinity constant for IL-8 to the receptors	Fixed	2.5E-3	0	Hour^-1
20	k _i1	Internalization rate for IL-8-R1 complex	Fixed	5.196	0	Hour^-1
21	$k_{i 1^{'}}$	Recycle rate for R1	Fixed	0.612	0	Hour^-1
22	k _i2	Internalization rate for IL-8-R2 complex	Fixed	20.796	0	Hour^-1
23	$k_{i 2^{'}}$	Recycle rate for R2	Fixed	0.144	0	Hour^-1
24	k _fMLP	Pathogen induced fMLP production	Fitted	5.9866E-7	1.3864E-6	nM*Hour^-1
25	$k_{f M L P}^{d}$	Pathogen induced fMLP production	Fitted	622.9280	1.6952E3	CFU
26	k _fMLP−D	Pathogen induced fMLP decay	Fitted	9.8425E4	1.7303E5	Hour^-1
27	$k_{f M L P - N_{B}}$	fMLP induced basal neutrophil to migratory-killer phenotype transition	Fitted	0.0021	0.0025	Hour^-1
28	k _ne	Scaling of Nk cells to neutrophil elastase / α1-PI complex levels	Fitted	0.0351	0.0209	ng/cell