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. 2015 Aug 6;7(9):2506–2519. doi: 10.1093/gbe/evv150

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© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2.— — SNP-permissive and shielding quartets in human ORFs. (A) Most frequent SNP-permissive (yellow) and SNP-shielding (red) A⇔G quartet contexts within the cDNA of CFTR. (B) Same analysis for cDNA of dystrophin. A statistical (chi square 2 × 2 contingency table) analysis indicated overrepresentation of shielding dinucleotide quartets in both genes (P < 0.00001), and underrepresentation of quartets permissive for SNP formation (P < 0.00001).

Fig. 2.— — SNP-permissive and shielding quartets in human ORFs. (A) Most frequent SNP-permissive (yellow) and SNP-shielding (red) A⇔G quartet contexts within the cDNA of CFTR. (B) Same analysis for cDNA of dystrophin. A statistical (chi square 2 × 2 contingency table) analysis indicated overrepresentation of shielding dinucleotide quartets in both genes (P < 0.00001), and underrepresentation of quartets permissive for SNP formation (P < 0.00001).