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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Ann N Y Acad Sci. 2015 Apr 15;1353(1):72–88. doi: 10.1111/nyas.12758

Figure 6.

Figure 6

Regulation of pro-fibrotic genes by diabetic conditions through Lin28-mediated inhibition of biogenesis of the let-7 family. TGF-β1 induced by diabetic conditions upregulates Lin28b through activation of Smad 2/3. Lin28b downregulates let-7 family miRNAs by inhibiting the processing of let-7. Decreased levels of let-7 members result in the upregulation of collagens (let-7 targets), leading to glomerular ECM protein accumulation and progression of DN, illustrating another circuit for signal perpetuation.