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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mucosal Immunol. 2015 Apr 15;8(6):1349–1359. doi: 10.1038/mi.2015.24

Figure 2. Post-vaccination increases in multifunctional (MF) CD8+TEM cells in PMBC from Ty21a vaccinees (n=16).

Figure 2

Induction of multiple cytokine (IFN-γ, TNF-α and/or IL-2)-producing and/or expressing CD107a CD8+TEM cells following stimulation with targets infected with S. Typhi (ST), S. Paratyphi A (PA) or S. Paratyphi B (PB). Data was analyzed using FCOM as described in the text. The post-vaccination peak increases (peak level at days 42 or 84 post-vaccination minus the corresponding pre-vaccination levels) in dominant subpopulations are shown as mean ± SEM (panel A). The percentage of responders was calculated as: (number of volunteers with peak post vaccination increases ≥0.1% in IFN-γ+CD107a+TNF-α-IL-2 subsets)/(total volunteers [n=16])X100 (panel B).

Horizontal bars represent mean ± SEM

**p<0.01; *p<0.05; #p<0.1 compared to IFN-γ+CD107a+TNF-α-IL-2- MF cells for each corresponding Salmonella-infected target. Other significance values relate to the indicated sets. Wilcoxon signed rank test, 2-tail (panel A). *p<0.05, by Chi square test 2-tail (panel B)