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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mucosal Immunol. 2015 Apr 15;8(6):1349–1359. doi: 10.1038/mi.2015.24

Fig. 6. Concomitant expression of the gut homing molecule integrin α4β7 by Salmonella-specific single and multifunctional CD8+TEM cells in Ty21a vaccinees.

Fig. 6

PBMC collected from Ty21a vaccinees were stimulated with S. Typhi (ST), S. Paratyphi A (PA) and S. Paratyphi B (PB)-infected targets and the data were analyzed using FCOM (described in the text). Shown are the peak post-vaccination increases in antigen-specific IFN-γ+ (panel A; n=12), CD107a+ (panel B; n=12), single positive (closed bars) and the sum of all multifunctional (open bars) cells in CD8+ TEM subpopulations expressing integrin α4β7 (α4β7 positives) or not (α4β7 negatives). Post-vaccination peaks: Peak responses at days 42 or 84 minus pre vaccination [day 0] levels Bars indicate mean ± SEM.

*p<0.05, #p≤ 0.1 compared to corresponding Single positive cells by Wilcoxon signed rank test, 2-tail. Other significance values relate to the indicated sets.