Table 2.
Projection density from subparaventricular zone subregions
Semiquantitative analysis of density of efferent projections from the four SPZ subregions: dlSPZ description and semiquantitative analysis was based on case 2567, which was compared to NVA140, NVA144, NVA44 for interpretation; vlSPZ description and semiquantitative analysis was based on case 2569; dmSPZ description and semiquantitative analysis was based on case NVA64, which was compared to NVA21, NVA22, NVA142 for interpretation; vmSPZ description and semiquantitative analysis was based on case NVA84, which was compared to NV37 for interpretation.
| Region | dlSPZ | vlSPZ | dmSPZ | vmSPZ |
|---|---|---|---|---|
| Basal Forebrain | ||||
| Lateral septal nucleus (LS) (predominantly ventral part) | +++ | ++ | + | +++ |
| Bed nucleus of the stria terminalis (BST) | +++(+) | ++(+) | +(+) | +++ |
| Parastrial nucleus (PS) | +++ | ++ | + | +++ |
| Diagonal band of Broca (DBB) | ++ | ++ | (+) | + |
| Organum vasculosum of the lamina terminalis (OVLT) | + | 0 | (+) | +++ |
| Substantia innominata (SI) | ++ | 0 | 0 | 0 |
| Hypothalamus | ||||
| Median pre-optic nucleus (MnPO) | (+) | (+) | (+) | +++ |
| Medial pre-optic nucleus (MPO) | ++ | + | (+) | ++ |
| Ventromedial pre-optic nucleus (VMPO) | +++ | + | + | ++++ |
| Ventrolateral pre-optic nucleus(VLPO) | + (+) | +(+) | + | ++ |
| Suprachiasmatic nucleus (SCN) | + | ++(+) | +(+) | +++(+) |
| Ventromedial subparaventricular zone (vmSPZ) | ++ | ++(+) | +++ | n/a |
| Ventrolateral subparaventricular zone (vlSPZ) | ++++ | n/a | + | ++++ |
| Dorsolateral subparaventricular zone (dlSPZ) | n/a | +++ | +(+) | +++ |
| Dorsomedial subparaventricular zone (dmSPZ) | + | + | n/a | +++ |
| Anteroventral periventricular nucleus (AVPe) | + | + | (+) | +++ |
| Anterior hypothalamic area (AHA) | ++++ | +++ | + (+) | +++ |
| Retrochiasmatic area (RCh) | ++(+) | ++(+) | +++ | ++(+) |
| Supraoptic nucleus (SO) | (+) | + | (+) | + |
| Supraoptic decussation (Sox) | +++ | +(+) | ++(+) | +++ |
| Supraoptic nucleus, retrochiasmatic part (SOR) | +++ | ++ | ++(+) | +++ |
| Paraventricular nucleus of the hypothalamus (PVH) - anterior parvicellular | +++ | ++ | ++(+) | +++(+) |
| Paraventricular nucleus of the hypothalamus (PVH) - middle | + | + | ++ | ++(+) |
| Paraventricular nucleus of the hypothalamus (PVH) - lateral wing | ++ | ++ | ++(+) | +++ |
| Dorsomedial nucleus of the hypothalamus (DMH) - anterior | +++(+) | +++ | +(+) | ++++ |
| Dorsomedial nucleus of the hypothalamus (DMH) - compact and surrounding | ++(+) | ++ | +(+) | ++(+) |
| Dorsomedial nucleus of the hypothalamus (DMH) - posterior | ++ | ++ | +(+) | +(+) |
| Lateral hypothalamic area (LHA) | +(+) | + | ++ | ++(+) |
| Ventromedial nucleus of the hypothalamus (VMH) – dorsomedial | +++++ | + | + | +++ |
| Ventromedial nucleus of the hypothalamus (VMH) - central | +++++ | ++ | (+) | +(+) |
| Ventromedial nucleus of the hypothalamus (VMH) - ventrolateral | ++++ | +++ | (+) | +(+) |
| Arcuate nucleus of the hypothalamus – medial | + | (+) | + | ++(+) |
| Arcuate nucleus of the hypothalamus – lateral | +++ | ++ | +(+) | +++(+) |
| Median eminence (ME) | + | + | ++++ | +++ |
| Supramammillary nucleus (SUM) | +++ | + | (+) | ++ |
| Medial mammillary nucleus (MM) | ++ | + | (+) | (+) |
| Mammillary body (edges) | ++ | ++ | ++ | +++ |
| Tuberomammillary nucleus (TMN) | ++(+) | ++ | + | ++ |
| Posterior hypothalamus | ++(+) | + | (+) | ++ |
| Pons and brainstem | ||||
| Periaqueductal/central gray (PAG/CG) | +++(+) | +++(+) | (+) | +++ |
| Ventral tegmental area (VTA) | ++ | + | + | + |
| Substantia nigra (SN) | (+) | (+) | (+) | (+) |
| Dorsal raphe nucleus (DR) | (+) | n/a | 0 | + |
| Pre-coeruleus | (+) | n/a | (+) | + |
| Locus coeruleus (LC) | 0 | n/a | 0 | (+) |
| Parabrachial nucleus (PB) | + | n/a | (+) | +(+) |
| Thalamus and habenula | ||||
| Paraventricular nucleus of the thalamus (PVT) - anterior | +++ | ++(+) | + | ++++ |
| Paraventricular nucleus of the thalamus (PVT) - middle | +++ | + | (+) | ++++ |
| Paraventricular nucleus of the thalamus (PVT) - posterior | ++ | + | (+) | +++ |
| Habenular nucleus of the nucleus (Hb) | +(+) | +(+) | 0 | (+) |
| Paratenial nucleus of the thalamus | ++ | ++ | (+) | ++ |
| Reuniens nucleus of the thalamus (Re) | + | ++ | (+) | ++(+) |
| Intergeniculate leaflet (IGL) | (+) | +(+) | 0 | + |
| Lateral geniculate nucleus of the thalamus (LGN) | (+) | (+) | 0 | +(+) |
| Cortical structures | ||||
| Medial nucleus of the Amygdala (MeA) | ++ | +(+) | ++ | ++ |
| Central nucleus of the Amygdala (CeA) | + | 0 | + | + |